Linked Life Data

20729767

Source:http://linkedlifedata.com/resource/pubmed/id/20729767

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2010-9-2
pubmed:abstractText
The aim was to investigate the relation between axonal outgrowth (neurofilaments) and Schwann cell activation (activating transcription factor 3) and apoptosis (caspase 3) 10 days after nerve repair with no, minor (3 mm defect) and moderate (6 mm defect) tension in rat sciatic nerve using immunohistochemistry. After repair with no tension, axons grew 11.75 mm, but repair with minor and moderate tension impaired axonal outgrowth by 29 and 48%, respectively, with a reduced number of activating transcription factor 3 stained and an increased number of caspase 3 stained Schwann cells. Axonal outgrowth correlated with activation of and inversely with apoptosis of Schwann cells. Tension induces impaired activation of Schwann cells, and a higher amount of apoptotic Schwann cells, with a subsequent deteriorated axonal outgrowth.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1473-558X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
6
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
958-62
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Impaired nerve regeneration and Schwann cell activation after repair with tension.
pubmed:affiliation
Department of Hand Surgery, Beijing Jishuitan Hospital, Beijing, PR China. drchuanjun@gmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't