| pubmed-article:20729328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C1539102 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C0916194 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:20729328 | lifeskim:mentions | umls-concept:C0521115 | lld:lifeskim |
| pubmed-article:20729328 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20729328 | pubmed:dateCreated | 2010-9-3 | lld:pubmed |
| pubmed-article:20729328 | pubmed:abstractText | Dectin-1, a C-type lectin recognizing fungal and mycobacterial pathogens, can deliver intracellular signals that activate dendritic cells (DCs), resulting in initiation of immune responses and expansion of Th17 CD4(+) T cell responses. In this paper, we studied the roles of human Dectin-1 (hDectin-1) expressed on DCs in the induction and activation of Ag-specific CD8(+) T cell responses. We first generated an agonistic anti-hDectin-1 mAb, which recognizes the hDectin-1 Glu(143)-Ile(162) region. It bound to in vitro monocyte-derived DCs and to in vivo CD1c(+)CD1a(+) dermal DCs but not to epidermal Langerhans cells. Anti-hDectin-1-mediated DC activation resulted in upregulation of costimulatory molecules and secretion of multiple cytokines and chemokines in a Syk-dependent manner. DCs activated with the anti-hDectin-1 mAb could significantly enhance both neo and foreign Ag-specific CD8(+) T cell responses by promoting both the expansion of CD8(+) T cells and their functional activities. We further demonstrated that delivering Ags to DCs via hDectin-1 using anti-hDectin-1-Ag conjugates resulted in potent Ag-specific CD8(+) T cell responses. Thus, hDectin-1 expressed on DCs can contribute to the induction and activation of cellular immunity against intracellular pathogens, such as mycobacteria, that are recognized by DCs via Dectin-1. Vaccines based on delivering Ags to DCs with an agonistic anti-hDectin-1 mAb could elicit CD8(+) T cell-mediated immunity. | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20729328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:20729328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20729328 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20729328 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:20729328 | pubmed:author | pubmed-author:ZurawskiSandr... | lld:pubmed |
| pubmed-article:20729328 | pubmed:author | pubmed-author:ZurawskiGerar... | lld:pubmed |
| pubmed-article:20729328 | pubmed:author | pubmed-author:BanchereauJac... | lld:pubmed |
| pubmed-article:20729328 | pubmed:author | pubmed-author:OhSangKonS | lld:pubmed |
| pubmed-article:20729328 | pubmed:author | pubmed-author:ClaytonSandra... | lld:pubmed |
| pubmed-article:20729328 | pubmed:author | pubmed-author:LiXiao-HuaXH | lld:pubmed |
| pubmed-article:20729328 | pubmed:author | pubmed-author:NiLingL | lld:pubmed |
| pubmed-article:20729328 | pubmed:author | pubmed-author:PaluckaAnna... | lld:pubmed |
| pubmed-article:20729328 | pubmed:author | pubmed-author:GayetIngridI | lld:pubmed |
| pubmed-article:20729328 | pubmed:author | pubmed-author:FlamarAnne-La... | lld:pubmed |
| pubmed-article:20729328 | pubmed:author | pubmed-author:O'BarAmyA | lld:pubmed |
| pubmed-article:20729328 | pubmed:author | pubmed-author:DulucDorothee... | lld:pubmed |
| pubmed-article:20729328 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20729328 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20729328 | pubmed:volume | 185 | lld:pubmed |
| pubmed-article:20729328 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20729328 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20729328 | pubmed:pagination | 3504-13 | lld:pubmed |
| pubmed-article:20729328 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:20729328 | pubmed:meshHeading | pubmed-meshheading:20729328... | lld:pubmed |
| pubmed-article:20729328 | pubmed:meshHeading | pubmed-meshheading:20729328... | lld:pubmed |
| pubmed-article:20729328 | pubmed:meshHeading | pubmed-meshheading:20729328... | lld:pubmed |
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| pubmed-article:20729328 | pubmed:meshHeading | pubmed-meshheading:20729328... | lld:pubmed |
| pubmed-article:20729328 | pubmed:meshHeading | pubmed-meshheading:20729328... | lld:pubmed |
| pubmed-article:20729328 | pubmed:meshHeading | pubmed-meshheading:20729328... | lld:pubmed |
| pubmed-article:20729328 | pubmed:meshHeading | pubmed-meshheading:20729328... | lld:pubmed |
| pubmed-article:20729328 | pubmed:meshHeading | pubmed-meshheading:20729328... | lld:pubmed |
| pubmed-article:20729328 | pubmed:meshHeading | pubmed-meshheading:20729328... | lld:pubmed |
| pubmed-article:20729328 | pubmed:meshHeading | pubmed-meshheading:20729328... | lld:pubmed |
| pubmed-article:20729328 | pubmed:meshHeading | pubmed-meshheading:20729328... | lld:pubmed |
| pubmed-article:20729328 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20729328 | pubmed:articleTitle | Concomitant activation and antigen uptake via human dectin-1 results in potent antigen-specific CD8+ T cell responses. | lld:pubmed |
| pubmed-article:20729328 | pubmed:affiliation | Baylor Institute for Immunology Research, Dallas, TX 75204, USA. | lld:pubmed |
| pubmed-article:20729328 | pubmed:publicationType | Journal Article | lld:pubmed |
