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rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0086418,
umls-concept:C0243144,
umls-concept:C0521115,
umls-concept:C0871261,
umls-concept:C0916194,
umls-concept:C1274040,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1539102,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C1879547,
umls-concept:C2698600,
umls-concept:C2911692
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pubmed:issue |
6
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pubmed:dateCreated |
2010-9-3
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pubmed:abstractText |
Dectin-1, a C-type lectin recognizing fungal and mycobacterial pathogens, can deliver intracellular signals that activate dendritic cells (DCs), resulting in initiation of immune responses and expansion of Th17 CD4(+) T cell responses. In this paper, we studied the roles of human Dectin-1 (hDectin-1) expressed on DCs in the induction and activation of Ag-specific CD8(+) T cell responses. We first generated an agonistic anti-hDectin-1 mAb, which recognizes the hDectin-1 Glu(143)-Ile(162) region. It bound to in vitro monocyte-derived DCs and to in vivo CD1c(+)CD1a(+) dermal DCs but not to epidermal Langerhans cells. Anti-hDectin-1-mediated DC activation resulted in upregulation of costimulatory molecules and secretion of multiple cytokines and chemokines in a Syk-dependent manner. DCs activated with the anti-hDectin-1 mAb could significantly enhance both neo and foreign Ag-specific CD8(+) T cell responses by promoting both the expansion of CD8(+) T cells and their functional activities. We further demonstrated that delivering Ags to DCs via hDectin-1 using anti-hDectin-1-Ag conjugates resulted in potent Ag-specific CD8(+) T cell responses. Thus, hDectin-1 expressed on DCs can contribute to the induction and activation of cellular immunity against intracellular pathogens, such as mycobacteria, that are recognized by DCs via Dectin-1. Vaccines based on delivering Ags to DCs with an agonistic anti-hDectin-1 mAb could elicit CD8(+) T cell-mediated immunity.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/R01 CA078846,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA078846-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA078846-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA078846-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA078846-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA078846-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA078846-06,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA078846-07,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA078846-08,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA078846-09,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA078846-10,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234-01,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234-010004,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234-010005,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234-02,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234-03,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234-04,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234-05,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234-06,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234-068130,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234-068136,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234-07,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234-078130,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234-078136,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI057234-08
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1550-6606
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pubmed:author |
pubmed-author:BanchereauJacquesJ,
pubmed-author:ClaytonSandraS,
pubmed-author:DulucDorotheeD,
pubmed-author:FlamarAnne-LaureAL,
pubmed-author:GayetIngridI,
pubmed-author:LiXiao-HuaXH,
pubmed-author:NiLingL,
pubmed-author:O'BarAmyA,
pubmed-author:OhSangKonS,
pubmed-author:PaluckaAnna KarolinaAK,
pubmed-author:ZurawskiGerardG,
pubmed-author:ZurawskiSandraS
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
185
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3504-13
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20729328-Amino Acid Sequence,
pubmed-meshheading:20729328-Animals,
pubmed-meshheading:20729328-Antibodies, Monoclonal,
pubmed-meshheading:20729328-Antibody Specificity,
pubmed-meshheading:20729328-Binding Sites, Antibody,
pubmed-meshheading:20729328-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20729328-Cell Line,
pubmed-meshheading:20729328-Cells, Cultured,
pubmed-meshheading:20729328-Dendritic Cells,
pubmed-meshheading:20729328-Epitopes, T-Lymphocyte,
pubmed-meshheading:20729328-Humans,
pubmed-meshheading:20729328-Membrane Proteins,
pubmed-meshheading:20729328-Mice,
pubmed-meshheading:20729328-Mice, Inbred BALB C,
pubmed-meshheading:20729328-Molecular Sequence Data,
pubmed-meshheading:20729328-Nerve Tissue Proteins,
pubmed-meshheading:20729328-Recombinant Fusion Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Concomitant activation and antigen uptake via human dectin-1 results in potent antigen-specific CD8+ T cell responses.
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pubmed:affiliation |
Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
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pubmed:publicationType |
Journal Article
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