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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0035647,
umls-concept:C0079419,
umls-concept:C0206063,
umls-concept:C0332293,
umls-concept:C0678214,
umls-concept:C0684249,
umls-concept:C0919524,
umls-concept:C1516213,
umls-concept:C1522449,
umls-concept:C1882417
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pubmed:issue |
5
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pubmed:dateCreated |
2011-3-18
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pubmed:abstractText |
Radiation-induced pneumonitis (RP) is the most common dose-limiting complication in lung cancer patients treated with radiotherapy. Accumulating evidence indicates that P53 and the ataxia telangiectasia-mutated protein (ATM)-dependent signaling response cascade play a crucial role in radiation-induced diseases. Consistent with this, our previous study showed that a functional genetic ATM polymorphism was associated with increased RP risk.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1879-355X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1402-7
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:20729006-Adult,
pubmed-meshheading:20729006-Aged,
pubmed-meshheading:20729006-Aged, 80 and over,
pubmed-meshheading:20729006-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:20729006-Cell Cycle Proteins,
pubmed-meshheading:20729006-DNA-Binding Proteins,
pubmed-meshheading:20729006-Female,
pubmed-meshheading:20729006-Genes, p53,
pubmed-meshheading:20729006-Genotype,
pubmed-meshheading:20729006-Humans,
pubmed-meshheading:20729006-Lung Neoplasms,
pubmed-meshheading:20729006-Male,
pubmed-meshheading:20729006-Middle Aged,
pubmed-meshheading:20729006-Polymorphism, Genetic,
pubmed-meshheading:20729006-Prospective Studies,
pubmed-meshheading:20729006-Protein-Serine-Threonine Kinases,
pubmed-meshheading:20729006-Radiation Pneumonitis,
pubmed-meshheading:20729006-Regression Analysis,
pubmed-meshheading:20729006-Risk,
pubmed-meshheading:20729006-Small Cell Lung Carcinoma,
pubmed-meshheading:20729006-Tumor Suppressor Proteins
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pubmed:year |
2011
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pubmed:articleTitle |
Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy.
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pubmed:affiliation |
Department of Etiology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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