Linked Life Data

20728473

Source:http://linkedlifedata.com/resource/pubmed/id/20728473

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-11-8
pubmed:abstractText
Orexin neurons, localized in the lateral hypothalamus area, synthesize two neuropeptides called orexin A and orexin B and send their axons to hippocampal formation including dentate gyrus (DG). Orexin A and orexin B act as endogenous ligands for two G-protein coupled receptors called orexin-1 and orexin-2 receptors (OX1R and OX2R). In the dentate gyrus (DG) region, OX1R, which has high affinity for orexin A, is expressed. Conflicting results have been reported regarding the effect of orexinergic system on synaptic plasticity. When given alone, SB-334867-A, a non-peptide OX1R antagonist, is a suitable drug to assess the natural and physiological significance of endogenous orexins. In the present research, we studied the effects of DG-OX1Rs antagonization on long-term potentiation (LTP) using two different high frequency stimulation (HFS) protocols i.e. 200 and 400 Hz in freely moving rats. The results showed that inactivation of DG-OX1Rs impair LTP induction in both HFS protocols which lasts beyond 24 h. This occurs with respect to both the population excitatory post-synaptic potential slope and population spike amplitude. Our findings suggest that endogenous orexins are involved in the expression of LTP, at least through DG-OX1Rs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1872-7549
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
216
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
375-80
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Orexin-1 receptor mediates long-term potentiation in the dentate gyrus area of freely moving rats.
pubmed:affiliation
Department of Physiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't