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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-31
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pubmed:abstractText |
Liver inflammation and injury are mediated by the innate immune response, which is regulated by Toll-like receptors (TLR). Activation of TLR9 induces type I interferons (IFNs) via the interferon regulatory factor (IRF)-7. We investigated the roles of type I IFNs in TLR9-associated liver injury.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ifnar1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Il1rn protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-7,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin 1 Receptor Antagonist...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/Irf7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Interferon alpha-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Tlr2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tlr9 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 9,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
697-708.e4
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pubmed:meshHeading |
pubmed-meshheading:20727895-Animals,
pubmed-meshheading:20727895-Cells, Cultured,
pubmed-meshheading:20727895-Dendritic Cells,
pubmed-meshheading:20727895-Hepatitis,
pubmed-meshheading:20727895-Hepatocytes,
pubmed-meshheading:20727895-Interferon Regulatory Factor-7,
pubmed-meshheading:20727895-Interferon Type I,
pubmed-meshheading:20727895-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:20727895-Interleukin-1beta,
pubmed-meshheading:20727895-Mice,
pubmed-meshheading:20727895-Mice, Inbred C57BL,
pubmed-meshheading:20727895-Receptor, Interferon alpha-beta,
pubmed-meshheading:20727895-Toll-Like Receptor 2,
pubmed-meshheading:20727895-Toll-Like Receptor 9,
pubmed-meshheading:20727895-Tumor Necrosis Factor-alpha,
pubmed-meshheading:20727895-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
Type I interferons protect from Toll-like receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice.
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pubmed:affiliation |
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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