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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2010-9-13
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pubmed:abstractText |
Synthesis of a diverse set of azoles and their utilizations as an amide isostere in the design of HIV integrase inhibitors is described. The Letter identified thiazole, oxazole, and imidazole as the most promising heterocycles. Initial SAR studies indicated that these novel series of integrase inhibitors are amenable to lead optimization. Several compounds with low nanomolar inhibitory potency are reported.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:CoatesJonathan A VJA,
pubmed-author:DeadmanJohn JJJ,
pubmed-author:JonesEric DED,
pubmed-author:LeGiangG,
pubmed-author:LiXinmingX,
pubmed-author:MORRWW,
pubmed-author:RhodesDavid IDI,
pubmed-author:ThienthongNeeranatN,
pubmed-author:VandegraaffNickN,
pubmed-author:WinfieldLisa JLJ,
pubmed-author:XiaoFengF,
pubmed-author:YuChangjiangC
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5909-12
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: azoles: effective metal chelators.
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pubmed:affiliation |
Avexa Ltd, 576 Swan Street, Richmond, Victoria 3121, Australia.
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pubmed:publicationType |
Journal Article
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