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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-4-19
pubmed:abstractText
Classic tissue effects of ?(2)-adrenergic receptor activation include skeletal muscle glycogenolysis and vascular smooth muscle relaxation, factors relevant to obesity and hypertension, respectively. In a population-based study, we examined 2 common amino acid substitutions in the ?(2)-adrenergic receptor gene (ADRB2) in relation to body composition and blood pressure. A cross-sectional analysis of 1893 African-descent men living in Tobago and participating in a prostate cancer screening study was performed. Body mass index, waist circumference, blood pressure, dual-energy x-ray absorptiometry body composition, and ADRB2 (Arg16Gly; Gln27Glu) genotype were determined. Twenty-six percent were obese (body mass index ?30 kg/m(2)), and 50% were hypertensive. ADRB2 Arg16Gly and Gln27Glu alleles were in linkage disequilibrium (D' = 0.96, r(2) = 0.15). ADRB2 16Gly-containing and 27Glu-containing genotypes were equally frequent in low, medium, and high tertiles of percentage of body fat mass (16Gly-containing genotypes: 73.4%, 74.4%, and 74.5%, P(trend) = .66; 27Glu-containing genotypes: 27.6%, 23.8%, and 25.4%, P(trend) = .39) and in normal blood pressure, prehypertensive, and hypertensive men (16Gly-containing genotypes: 73.4%, 72.8%, and 74.4%, P(trend) = .61; 27Glu-containing genotypes: 25.6%, 24.1%, and 26.7%, P(trend) = .50). In a high-obesity and high-hypertension risk population with ancestry in common with African Americans, genetic variation defined by 2 common ADRB2 amino acid substitutions was not associated with body composition or hypertension.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1532-8600
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
698-705
pubmed:meshHeading
pubmed-meshheading:20727557-Absorptiometry, Photon, pubmed-meshheading:20727557-Adult, pubmed-meshheading:20727557-African Continental Ancestry Group, pubmed-meshheading:20727557-Aged, pubmed-meshheading:20727557-Blood Pressure, pubmed-meshheading:20727557-Body Composition, pubmed-meshheading:20727557-Body Mass Index, pubmed-meshheading:20727557-Cross-Sectional Studies, pubmed-meshheading:20727557-Humans, pubmed-meshheading:20727557-Hypertension, pubmed-meshheading:20727557-Linkage Disequilibrium, pubmed-meshheading:20727557-Male, pubmed-meshheading:20727557-Middle Aged, pubmed-meshheading:20727557-Obesity, pubmed-meshheading:20727557-Polymorphism, Genetic, pubmed-meshheading:20727557-Receptors, Adrenergic, beta-2, pubmed-meshheading:20727557-Trinidad and Tobago, pubmed-meshheading:20727557-Waist Circumference
pubmed:year
2011
pubmed:articleTitle
ADRB2 gene variants, dual-energy x-ray absorptiometry body composition, and hypertension in Tobago men of African descent.
pubmed:affiliation
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural