Source:http://linkedlifedata.com/resource/pubmed/id/20727557
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2011-4-19
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pubmed:abstractText |
Classic tissue effects of ?(2)-adrenergic receptor activation include skeletal muscle glycogenolysis and vascular smooth muscle relaxation, factors relevant to obesity and hypertension, respectively. In a population-based study, we examined 2 common amino acid substitutions in the ?(2)-adrenergic receptor gene (ADRB2) in relation to body composition and blood pressure. A cross-sectional analysis of 1893 African-descent men living in Tobago and participating in a prostate cancer screening study was performed. Body mass index, waist circumference, blood pressure, dual-energy x-ray absorptiometry body composition, and ADRB2 (Arg16Gly; Gln27Glu) genotype were determined. Twenty-six percent were obese (body mass index ?30 kg/m(2)), and 50% were hypertensive. ADRB2 Arg16Gly and Gln27Glu alleles were in linkage disequilibrium (D' = 0.96, r(2) = 0.15). ADRB2 16Gly-containing and 27Glu-containing genotypes were equally frequent in low, medium, and high tertiles of percentage of body fat mass (16Gly-containing genotypes: 73.4%, 74.4%, and 74.5%, P(trend) = .66; 27Glu-containing genotypes: 27.6%, 23.8%, and 25.4%, P(trend) = .39) and in normal blood pressure, prehypertensive, and hypertensive men (16Gly-containing genotypes: 73.4%, 72.8%, and 74.4%, P(trend) = .61; 27Glu-containing genotypes: 25.6%, 24.1%, and 26.7%, P(trend) = .50). In a high-obesity and high-hypertension risk population with ancestry in common with African Americans, genetic variation defined by 2 common ADRB2 amino acid substitutions was not associated with body composition or hypertension.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1532-8600
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pubmed:author | |
pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
698-705
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pubmed:meshHeading |
pubmed-meshheading:20727557-Absorptiometry, Photon,
pubmed-meshheading:20727557-Adult,
pubmed-meshheading:20727557-African Continental Ancestry Group,
pubmed-meshheading:20727557-Aged,
pubmed-meshheading:20727557-Blood Pressure,
pubmed-meshheading:20727557-Body Composition,
pubmed-meshheading:20727557-Body Mass Index,
pubmed-meshheading:20727557-Cross-Sectional Studies,
pubmed-meshheading:20727557-Humans,
pubmed-meshheading:20727557-Hypertension,
pubmed-meshheading:20727557-Linkage Disequilibrium,
pubmed-meshheading:20727557-Male,
pubmed-meshheading:20727557-Middle Aged,
pubmed-meshheading:20727557-Obesity,
pubmed-meshheading:20727557-Polymorphism, Genetic,
pubmed-meshheading:20727557-Receptors, Adrenergic, beta-2,
pubmed-meshheading:20727557-Trinidad and Tobago,
pubmed-meshheading:20727557-Waist Circumference
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pubmed:year |
2011
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pubmed:articleTitle |
ADRB2 gene variants, dual-energy x-ray absorptiometry body composition, and hypertension in Tobago men of African descent.
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pubmed:affiliation |
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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