Linked Life Data

2072751

Source:http://linkedlifedata.com/resource/pubmed/id/2072751

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1991-8-20
pubmed:abstractText
Lymphocyte migration to lymphoid organs involves tissue-specific homing receptors. A lectin-like surface glycoprotein of 80 kD, the LECAM-1 (LAM-1, Leu-8) antigen, has recently been shown to represent the human equivalent of the mouse peripheral lymph node homing receptor MEL-14. In this study, the expression of LECAM-1 was examined in 116 nodal and 53 gastrointestinal (GI) non-Hogdkin's lymphomas (NHL). This analysis revealed that whereas the majority of nodal lymphomas expressed LECAM-1, this molecule was generally absent on GI lymphomas. This difference was present in each subclass of lymphomas but was most significant among diffuse large-cell lymphomas of the B-lineage (83 versus 23%, p less than 0.0001) and among T-cell lymphomas (89 versus 0%, p less than 0.0001) with a nodal versus GI tract localization. The strong correlation between LECAM-1 expression and the localization of the lymphomas supports the concept that tissue-specific homing receptors, i.e. LECAM-1, play a role in the dissemination of NHL.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0887-6924
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
628-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Expression of the human peripheral lymph node homing receptor (LECAM-1) in nodal and gastrointestinal non-Hodgkin's lymphomas.
pubmed:affiliation
Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't