20726512

Source:http://linkedlifedata.com/resource/pubmed/id/20726512

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003864, umls-concept:C0006826, umls-concept:C0007222, umls-concept:C0038761, umls-concept:C0205177, umls-concept:C0205531, umls-concept:C0226896, umls-concept:C0243077, umls-concept:C0442027, umls-concept:C0623362, umls-concept:C1527415
pubmed:issue	18
pubmed:dateCreated	2010-9-16
pubmed:abstractText	?-Sulfone-?-piperidine and ?-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP's-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy in rats and in the bovine cartilage degradation ex vivo explant system. ?-Piperidine 19v (SC-78080/SD-2590) was selected for development toward the initial indication of cancer, while ?-piperidine and ?-tetrahydropyranyl hydroxamates 19w (SC-77964) and 9i (SC-77774), respectively, were identified as backup compounds.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9716531
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Cardiovascular Agents, http://linkedlifedata.com/resource/pubmed/chemical/Hydroxamic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 1, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases, http://linkedlifedata.com/resource/pubmed/chemical/Piperidines, http://linkedlifedata.com/resource/pubmed/chemical/Pyrans, http://linkedlifedata.com/resource/pubmed/chemical/Sulfones
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	1520-4804
pubmed:author	pubmed-author:BartaThomas ETE, pubmed-author:BeckerDaniel PDP, pubmed-author:BedellLouis JLJ, pubmed-author:BoehmTerri LTL, pubmed-author:BondBrian RBR, pubmed-author:CarrollJefferyJ, pubmed-author:CarronChris PCP, pubmed-author:DecrescenzoGary AGA, pubmed-author:EastonAlan MAM, pubmed-author:FreskosJohn NJN, pubmed-author:Funckes-ShippyChris LCL, pubmed-author:HeronMarciaM, pubmed-author:HockermanSusanS, pubmed-author:HowardCarol PearcyCP, pubmed-author:KieferJames RJR, pubmed-author:LiMadeleine HMH, pubmed-author:MathisKarl JKJ, pubmed-author:McDonaldJoseph JJJ, pubmed-author:MehtaPramod PPP, pubmed-author:MunieGrace EGE, pubmed-author:RodT OTO, pubmed-author:SunyerTeresaT, pubmed-author:SwearingenCraig ACA, pubmed-author:VillamilClara ICI, pubmed-author:WelschDeanD, pubmed-author:WilliamsJennifer MJM, pubmed-author:YuYingY
pubmed:issnType	Electronic
pubmed:day	23
pubmed:volume	53
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	6653-80
pubmed:meshHeading	pubmed-meshheading:20726512-Animals, pubmed-meshheading:20726512-Anti-Inflammatory Agents, pubmed-meshheading:20726512-Antineoplastic Agents, pubmed-meshheading:20726512-Biological Availability, pubmed-meshheading:20726512-Cardiovascular Agents, pubmed-meshheading:20726512-Cartilage, Articular, pubmed-meshheading:20726512-Cattle, pubmed-meshheading:20726512-Crystallography, X-Ray, pubmed-meshheading:20726512-Humans, pubmed-meshheading:20726512-Hydroxamic Acids, pubmed-meshheading:20726512-Hypertrophy, Left Ventricular, pubmed-meshheading:20726512-Macaca fascicularis, pubmed-meshheading:20726512-Matrix Metalloproteinase 1, pubmed-meshheading:20726512-Matrix Metalloproteinases, pubmed-meshheading:20726512-Mice, pubmed-meshheading:20726512-Mice, Nude, pubmed-meshheading:20726512-Models, Molecular, pubmed-meshheading:20726512-Molecular Structure, pubmed-meshheading:20726512-Piperidines, pubmed-meshheading:20726512-Pyrans, pubmed-meshheading:20726512-Rats, pubmed-meshheading:20726512-Structure-Activity Relationship, pubmed-meshheading:20726512-Sulfones, pubmed-meshheading:20726512-Xenograft Model Antitumor Assays
pubmed:year	2010
pubmed:articleTitle	Orally active MMP-1 sparing ?-tetrahydropyranyl and ?-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.
pubmed:affiliation	Pfizer Research, 700 Chesterfield Village Parkway, St. Louis, Missouri 63198, USA. dbecke3@luc.edu
pubmed:publicationType	Journal Article