Linked Life Data

20725645

Source:http://linkedlifedata.com/resource/pubmed/id/20725645

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-10-8
pubmed:abstractText
Protein crystallography, the main experimental method of structural biology, has undergone in the recent past three revolutionary changes leading to its unexpected renaissance. They were connected with (i) the introduction of synchrotron radiation sources for X-ray diffraction experiments, (ii) implementation of Se-Met multiwavelength anomalous diffraction (MAD) for phasing, and (iii) initiation of structural genomics (SG) programs. It can be foreseen that in the next 10-15 years protein crystallography will continue to be in this revolutionary phase. We can expect not only an avalanche of protein crystal structures from SG centers, but also attacking of more demanding projects, such as the structure of membrane proteins and of very large macromolecular complexes. On the technological front, the introduction of X-ray radiation from free-electron lasers will revolutionize the experimental possibilities, making feasible even the imaging of single molecules and of intact biological cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1734-154X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
261-4
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Personal remarks on the future of protein crystallography and structural biology.
pubmed:affiliation
Department of Crystallography, Faculty of Chemistry, Adam Mickiewicz University, and Center for Biocrystallographic Research, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Pozna?, Poland. mariuszj@amu.edu.pl
pubmed:publicationType
Journal Article, Review