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pubmed:abstractText |
Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active against first-stage HAT only, prior to the parasites causing neurological deterioration through invasion of the CNS. A major research effort to design novel diamidines has led to the development of orally active prodrugs and, remarkably, a new generation of compounds that can penetrate the CNS. In this review, progress in the development of diamidines for the treatment of HAT is discussed.
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pubmed:affiliation |
University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Campus Box 7569, and Department of Pathology and Laboratory Medicine, Campus Box 7525, Chapel Hill, NC 27599, USA
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