Linked Life Data

20720564

Source:http://linkedlifedata.com/resource/pubmed/id/20720564

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-12-15
pubmed:abstractText
Type I IFNs (IFN?/?) have been shown to have a central role in the pathophysiology of lupus erythematosus (LE). The recently discovered type III IFNs (IFN?1/IL29, IFN?2/IL28a, IFN?3/IL28b) share several functional similarities with type I IFNs, particularly in antiviral immunity. As IFN?s act primarily on epithelial cells, we investigated whether type III IFNs might also have a role in the pathogenesis of cutaneous LE (CLE). Our investigations demonstrate that IFN? and the IFN? receptor were strongly expressed in the epidermis of CLE skin lesions and related autoimmune diseases (lichen planus and dermatomyositis). Significantly enhanced IFN?1 could be measured in the serum of CLE patients with active skin lesions. Functional analyses revealed that human keratinocytes are able to produce high levels of IFN?1 but only low amounts of IFN?/?/? in response to immunostimulatory nuclear acids, suggesting that IFN? is a major IFN produced by these cells. Exposure of human keratinocytes to IFN?1 induced the expression of several proinflammatory cytokines, including CXCL9 (CXC-motiv ligand 9), which drive the recruitment of immune cells and are associated with the formation of CLE skin lesions. Our results provide evidence for a role of type III IFNs in not only antiviral immunity but also autoimmune diseases of the skin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1523-1747
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-40
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFN?) in cutaneous lupus erythematosus.
pubmed:affiliation
Department of Dermatology and Allergology, University of Bonn, Bonn, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't