Linked Life Data

2072049

Source:http://linkedlifedata.com/resource/pubmed/id/2072049

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-8-20
pubmed:abstractText
Studies of men and animal models have reported informally that gossypol reduces fertility without behavioral disruptions. In the present research, we used an animal model and quantitative psychobiologic methods to examine the capacity of gossypol to suppress sperm reserves and to maintain both libido and performance. Sexually experienced male rats were exposed for 11 weeks to either 5, 10 or 20 mg gossypol/kg body weight, values representing the moderate to threshold dosages for induction of sterility. Behavioral changes over weeks of administration and reproductive physiology at necropsy were measured. Results showed that the expected dose-response reduction in gamete quantity and quality was accompanied by reductions in reproductive organ weights and copulatory performance, but the reductions were modest and principally with the higher dosages. On the other hand, there was the suggestion of a dose-response suppression of motivation, or interest in seeking and maintaining contact with a receptive female. Indeed, the characteristic pattern of a progressive loss of sperm motility and numbers with dose and time of exposure to gossypol closely paralleled the pattern of behavioral decrements. Implications of the data are that: 1.) gossypol may induce sterility in males at the expense of loss of motivation, and 2.) sexual performance and libido can vary in dependently. Future assessments of a substance under consideration as a contraceptive agent should consider quantitative measurement of both components of sexual behavior.
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/Americas, http://linkedlifedata.com/resource/pubmed/keyword/Animals, Laboratory, http://linkedlifedata.com/resource/pubmed/keyword/Behavior, http://linkedlifedata.com/resource/pubmed/keyword/Biology, http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research, http://linkedlifedata.com/resource/pubmed/keyword/Contraception, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Male, http://linkedlifedata.com/resource/pubmed/keyword/Control Groups, http://linkedlifedata.com/resource/pubmed/keyword/Decreased Libido, http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries, http://linkedlifedata.com/resource/pubmed/keyword/Europe, http://linkedlifedata.com/resource/pubmed/keyword/Examinations And Diagnoses, http://linkedlifedata.com/resource/pubmed/keyword/Family Planning, http://linkedlifedata.com/resource/pubmed/keyword/GERMANY, http://linkedlifedata.com/resource/pubmed/keyword/GOSSYPOL, http://linkedlifedata.com/resource/pubmed/keyword/Gynecologic Surgery, http://linkedlifedata.com/resource/pubmed/keyword/Histology, http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Examinations And Diagnoses, http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Procedures, http://linkedlifedata.com/resource/pubmed/keyword/MISSOURI, http://linkedlifedata.com/resource/pubmed/keyword/Male Contraception, http://linkedlifedata.com/resource/pubmed/keyword/Methodological Studies, http://linkedlifedata.com/resource/pubmed/keyword/North America, http://linkedlifedata.com/resource/pubmed/keyword/Northern America, http://linkedlifedata.com/resource/pubmed/keyword/Ovariectomy, http://linkedlifedata.com/resource/pubmed/keyword/Physiology, http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology, http://linkedlifedata.com/resource/pubmed/keyword/Sex Behavior--changes, http://linkedlifedata.com/resource/pubmed/keyword/Sperm Count--changes, http://linkedlifedata.com/resource/pubmed/keyword/Surgery, http://linkedlifedata.com/resource/pubmed/keyword/Treatment, http://linkedlifedata.com/resource/pubmed/keyword/United States, http://linkedlifedata.com/resource/pubmed/keyword/Urogenital Surgery, http://linkedlifedata.com/resource/pubmed/keyword/Western Europe
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0025-7850
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
29-44
pubmed:dateRevised
2006-11-15
pubmed:otherAbstract
PIP: Researchers from the University of Missouri and the German Cancer Research Center compared sperm characteristics and sexual behavior of 32 150-day old Long Evans male rats who received doses of either 0, 5, 10, or 20 mg gossypol/kg body weight to learn motivation in seeking sexual contact with a receptive female and copulatory effectiveness in relation to epididymal sperm reserves and endocrine target tissues. Females included gonadally intact and ovariectomized rats. Even though none of the male rates experienced azoospermia after 11 weeks of receiving gossypol, significant reductions in sperm concentrations and motility occurred for those receiving 10-20 mg/kg body weight (p.01) indicating possible infertility. No changes in reproductive physiology (weight of sex organs) and sexual performance occurred between the control rats and those receiving 5 mg gossypol, but changes did occur between the control rats and both those receiving 10 and 20 mg gossypol. Sexual motivation fell as the dosage of gossypol increased. In fact, the interaction of amount and duration affected suppression. The gradual suppression of serum testosterone may have been responsible for the decline in libido. These results suggest that gossypol may indeed cause sterility, but also may reduce the libido. In addition, they show that sexual performance and motivation can differ independently.
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Search for a male contraceptive: the effect of gossypol on sexual motivation and epididymal sperm.
pubmed:affiliation
Institute for Experimental Pathology, German Cancer Research Center, Heidelberg.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't