Linked Life Data

20718658

Source:http://linkedlifedata.com/resource/pubmed/id/20718658

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-10-19
pubmed:abstractText
IgM is the first antibody produced during the immune response to infection or immunization, and it can be secreted as pentamer (containing a small polypeptide, termed as J chain) or hexamer (lacking J chain). In this paper we have analyzed structural characteristics (by electrophoresis and immunoblot) and anti-bacterial specificity (by enzyme-linked immunosorbent assay) of IgM antibodies purified from female patients suffering from recurrent bacterial infections of lower urinary tract and therapeutically immunized with the mixture of heat-inactivated uropathogenic bacteria. We report on changes in the composition of IgM polymers in tested patients. The immunization induced the raise of the levels of hexamers in patients that did not respond to immunization (non-responders), while the IgM polymers remained on the pentameric level in immunization dependent responders. We propose that the composition of IgM polymers could influence the immunization outcome and should be taken in count regarding the treatment of recurrent bacterial infections.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1532-4311
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
781-95
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Changes in composition of IgM polymers in patients suffering from recurrent urinary bacterial infections after bacterial immunization treatment.
pubmed:affiliation
Institute of Virology, Vaccines and Sera - Torlak, Department of Research and Development, Belgrade, Serbia. vzpetrusic@gmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't