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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2010-9-16
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pubmed:abstractText |
(R,S)-anti-1-amino-2-fluorocyclopentyl-1-carboxylic acid (2-FACPC, 4b) was radiolabeled in 39% yield starting from cyclic sulfamidate 12. The 9L gliosarcoma cells assays showed that 4b is mainly a substrate for the L-type amino acid transport with some affinity to the A-type. In rats bearing 9L gliosarcoma tumors, 4b displayed high tumor to brain ratio (10:1) at 120 min after injection. FACPC is an attractive candidate for imaging brain tumors with PET, and its isolated enantiomers are under investigation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1520-4804
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
23
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6603-7
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pubmed:meshHeading |
pubmed-meshheading:20718421-Amino Acid Transport System y+L,
pubmed-meshheading:20718421-Animals,
pubmed-meshheading:20718421-Brain,
pubmed-meshheading:20718421-Brain Neoplasms,
pubmed-meshheading:20718421-Cell Line, Tumor,
pubmed-meshheading:20718421-Cycloleucine,
pubmed-meshheading:20718421-Cyclopentanes,
pubmed-meshheading:20718421-Fluorine Radioisotopes,
pubmed-meshheading:20718421-Male,
pubmed-meshheading:20718421-Positron-Emission Tomography,
pubmed-meshheading:20718421-Radiopharmaceuticals,
pubmed-meshheading:20718421-Rats,
pubmed-meshheading:20718421-Rats, Inbred F344,
pubmed-meshheading:20718421-Stereoisomerism,
pubmed-meshheading:20718421-Structure-Activity Relationship,
pubmed-meshheading:20718421-Tissue Distribution
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pubmed:year |
2010
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pubmed:articleTitle |
(R,S)-anti-1-amino-2-[18F]fluorocyclopentyl-1-carboxylic acid: synthesis from racemic 2-benzyloxycyclopentanone and biological evaluation for brain tumor imaging with positron emission tomography.
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pubmed:affiliation |
Department of Radiology, Emory University CSI, Wesley Woods Health Center, 1841 Clifton Road, NE, Atlanta, Georgia 30329, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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