Linked Life Data

2071829

Source:http://linkedlifedata.com/resource/pubmed/id/2071829

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-8-16
pubmed:abstractText
Chromosome analysis was carried out in resident and exudate peritoneal macrophages and, also, in bone marrow cells of groups of mice either immunized with ovalbumin in complete Freund's adjuvant and challenged with the antigen, or stimulated with the irritant thioglycollic acid. Labeling of the phagocytic cells with colloidal carbon showed that dividing cells in the peritoneal cavity of experimental mice are resident macrophages. Also shown was an increase in number of hyperdiploid metaphases in hyperimmune, older mice but not in the young ones. Statistical analysis showed these differences to be significant. G-banding of hyperdiploid cells of hyperimmune older mice showed trisomy of chromosome 15 in several metaphases analyzed. The absence of hyperdiploid metaphases in the bone marrow cells of hyperimmune mice and in exudate macrophages of mice that received the irritant thioglycollic acid suggests that hyperdiploidy occurs in resident macrophages in the peritoneal cavity but not in their precursors in the bone marrow. These results raise some questions such as, hyperimmune older mice resident macrophages being prone to hyperdiploidy and trisomy of chromosome 15.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-1422
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
B148-51
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Hyperdiploidy and trisomy of chromosome 15 in peritoneal macrophages of hyperimmune, older Swiss mice.
pubmed:affiliation
Department of Genetics and Morphology, University of Brasilia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't