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pubmed-article:20717951pubmed:abstractTextThe symptoms of allergic rhinitis result from an immunoglobulin E-dependent mast cell activation cascade, marked by the release of inflammatory mediators, including histamine. Patients with perennial allergic rhinitis also have elevated levels of cysteinyl leukotrienes (CysLTs) in nasal lavage fluid. Histamine and CysLTs produce different responses in the pathogenesis of allergic rhinitis, and this study tested the hypothesis that the effects of combined antihistamine and leukotriene antagonist therapy would be more effective than antihistamine alone.lld:pubmed
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pubmed-article:20717951pubmed:articleTitleEfficacy of leukotriene antagonists as concomitant therapy in allergic rhinitis.lld:pubmed
pubmed-article:20717951pubmed:affiliationDepartment of Otorhinolaryngology and Head-Neck Surgery, Osmangazi University, Eskisehir, Turkey.lld:pubmed
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