rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-8-18
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pubmed:abstractText |
DOG1 and protein kinase C (PKC) theta are both sensitive immunohistochemical markers of gastrointestinal stromal tumour (GIST). However, there are conflicting data regarding the specificity of the most commonly used PKC theta antibody (clone 27), and there are no existing data regarding the specificity of the only known commercially available DOG1 antibody (K9 clone) at the time of writing. This study's aim was to characterize the immunoreactivity patterns of both monoclonal antibodies amongst a wide range of neoplasm types including, in particular, histological mimics of GIST.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ANO1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PRKCQ protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-kit,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1365-2559
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
250-8
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pubmed:meshHeading |
pubmed-meshheading:20716167-Antibodies, Monoclonal,
pubmed-meshheading:20716167-Diagnosis, Differential,
pubmed-meshheading:20716167-Gastrointestinal Stromal Tumors,
pubmed-meshheading:20716167-Humans,
pubmed-meshheading:20716167-Immunohistochemistry,
pubmed-meshheading:20716167-Isoenzymes,
pubmed-meshheading:20716167-Membrane Proteins,
pubmed-meshheading:20716167-Neoplasm Proteins,
pubmed-meshheading:20716167-Neoplasms,
pubmed-meshheading:20716167-Observer Variation,
pubmed-meshheading:20716167-Protein Kinase C,
pubmed-meshheading:20716167-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:20716167-Sensitivity and Specificity,
pubmed-meshheading:20716167-Tumor Markers, Biological
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pubmed:year |
2010
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pubmed:articleTitle |
Specificity of DOG1 (K9 clone) and protein kinase C theta (clone 27) as immunohistochemical markers of gastrointestinal stromal tumour.
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pubmed:affiliation |
Department of Histopathology, Bristol Royal Infirmary, Marlborough Street, Bristol, UK. nacs.wong@bristol.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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