Linked Life Data

20715810

Source:http://linkedlifedata.com/resource/pubmed/id/20715810

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-9-13
pubmed:abstractText
The Pipecolic linker is a new highly versatile handle which immobilizes on solid support through a carboxylic acid function a wide range of amines, alcohols, and hydrazines. The anchoring step on pipecolic resin is very easy and efficient, and compounds are released with high purities upon acidic treatment. During this treatment, an oxazolonium intermediate is hydrolyzed, yielding the cleavage of ester or amide bond and the release of free carboxylic acid of the starting linker. In this study, we report the possibility of recycling the pipecolic resin after the use of several trifluoroacetic acid (TFA) cleavage cocktails. We demonstrate that it can be reused up to five times without significant loading decrease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1520-4774
pubmed:author
pubmed:issnType
Electronic
pubmed:day
13
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
747-53
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Recycling the versatile Pipecolic linker.
pubmed:affiliation
IBMM, Institut des Biomolécules Max Mousseron, UMR 5247, Universités Montpellier I and II, CNRS, Faculté de Pharmacie, 15 av. C. Flahault, BP 14491, 34093 Montpellier Cedex 05, France.
pubmed:publicationType
Journal Article