Source:http://linkedlifedata.com/resource/pubmed/id/20713986
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2010-10-21
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| pubmed:abstractText |
Phosphorylation of fascin at serine 39 (phospho-S39-fascin) could inhibit its actin-binding and actin-bundling activities and decrease filopodia formation. However, the relationship between phospho-S39-fascin expression and clinicopathological parameters in tumors is still unknown. Here, Western blot analysis and IHC applied to tissue microarray technology were performed to examine the expression status of non-phosphorylated fascin (fascin) and phospho-S39-fascin and their impacts on the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Fascin and phospho-S39-fascin expressions were tested by cytoplasmic staining. Among the 254 patients, 90 cases showed high expression of fascin and 87 cases showed high expression of phospho-S39-fascin. Survival analysis showed that high expression of fascin was significantly associated with a poor prognosis of the patients with ESCC (p=0.004). In contrast, high expression of phospho-S39-fascin correlated significantly with an improved outcome of patients (p=0.020). Multivariate analysis showed that both fascin and phospho-S39-fascin were independent prognostic factors. In a combined analysis, the patients with high expression of fascin and low expression of phospho-S39-fascin tumors had a shorter overall survival than those with high expression of both fascin and phospho-S39-fascin tumors (5-year overall survival rate: 28.7% vs 48.3%, p=0.068). Our results suggest that high expression of fascin correlates with poor outcome and that high expression of phospho-S39-fascin decreases the risk of poor prognosis in ESCC. This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/fascin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
|
| pubmed:issn |
1551-5044
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| pubmed:author |
pubmed-author:HuangQiaoQ,
pubmed-author:LiEn-MinEM,
pubmed-author:LuXiao-FengXF,
pubmed-author:ShenJin-HuiJH,
pubmed-author:ShenZhong-YingZY,
pubmed-author:WuJian-YiJY,
pubmed-author:WuZhi-YongZY,
pubmed-author:XieJian-JunJJ,
pubmed-author:XuLi-YanLY,
pubmed-author:XuXiu-EXE,
pubmed-author:ZhaoQingQ
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| pubmed:issnType |
Electronic
|
| pubmed:volume |
58
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
979-88
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| pubmed:dateRevised |
2011-11-1
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| pubmed:meshHeading |
pubmed-meshheading:20713986-Adult,
pubmed-meshheading:20713986-Aged,
pubmed-meshheading:20713986-Animals,
pubmed-meshheading:20713986-Antibody Specificity,
pubmed-meshheading:20713986-Carcinoma, Squamous Cell,
pubmed-meshheading:20713986-Carrier Proteins,
pubmed-meshheading:20713986-Cell Line, Tumor,
pubmed-meshheading:20713986-Esophageal Neoplasms,
pubmed-meshheading:20713986-Female,
pubmed-meshheading:20713986-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20713986-Humans,
pubmed-meshheading:20713986-Male,
pubmed-meshheading:20713986-Microfilament Proteins,
pubmed-meshheading:20713986-Middle Aged,
pubmed-meshheading:20713986-Phosphoproteins,
pubmed-meshheading:20713986-Phosphorylation,
pubmed-meshheading:20713986-Prognosis,
pubmed-meshheading:20713986-Risk,
pubmed-meshheading:20713986-Serine,
pubmed-meshheading:20713986-Survival Analysis
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| pubmed:year |
2010
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| pubmed:articleTitle |
Phosphorylation of fascin decreases the risk of poor survival in patients with esophageal squamous cell carcinoma.
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| pubmed:affiliation |
Institute of Oncologic Pathology, Medical College of Shantou University, Shantou, Guangdong, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|