Source:http://linkedlifedata.com/resource/pubmed/id/20713884
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2010-9-3
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| pubmed:abstractText |
The beta-herpesvirus CMV induces a substantial and progressive expansion of virus-specific memory CD8 T cells, which protect the host against viral reactivation from latency. In this paper, we report that this expansion, or "inflation," of memory T cells is amplified dramatically during mouse CMV infection of IL-10 knockout (IL-10(-/-)) mice. T cells from IL-10(-/-) mice were oligoclonal, exhibited a highly activated phenotype, expressed antiviral cytokines, and degranulated in response to cognate Ag encounter ex vivo. Moreover, latent viral load was reduced in IL-10(-/-) mice. Importantly, these results were recapitulated by IL-10R blockade during chronic/latent infection of wild-type mice. These data demonstrate that regulatory immune mechanisms can influence CMV-specific T cell memory and suggest a possible rationale for the acquisition of functional IL-10 orthologs by herpesviruses.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1550-6606
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
185
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3583-92
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| pubmed:meshHeading |
pubmed-meshheading:20713884-Amino Acid Sequence,
pubmed-meshheading:20713884-Animals,
pubmed-meshheading:20713884-BALB 3T3 Cells,
pubmed-meshheading:20713884-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20713884-Cell Differentiation,
pubmed-meshheading:20713884-Chronic Disease,
pubmed-meshheading:20713884-Epitopes, T-Lymphocyte,
pubmed-meshheading:20713884-Growth Inhibitors,
pubmed-meshheading:20713884-Herpesviridae Infections,
pubmed-meshheading:20713884-Immunologic Memory,
pubmed-meshheading:20713884-Interleukin-10,
pubmed-meshheading:20713884-Mice,
pubmed-meshheading:20713884-Mice, Inbred BALB C,
pubmed-meshheading:20713884-Mice, Inbred C57BL,
pubmed-meshheading:20713884-Mice, Knockout,
pubmed-meshheading:20713884-Molecular Sequence Data,
pubmed-meshheading:20713884-Muromegalovirus,
pubmed-meshheading:20713884-T-Lymphocyte Subsets,
pubmed-meshheading:20713884-Virus Latency
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
IL-10 restricts memory T cell inflation during cytomegalovirus infection.
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| pubmed:affiliation |
Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, United Kingdom.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|