Linked Life Data

20712893

Source:http://linkedlifedata.com/resource/pubmed/id/20712893

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-9-6
pubmed:abstractText
X-linked inhibitor of apoptosis protein (XIAP) is often overexpressed in cancer cells, where it plays a key role in survival and also promotes invasiveness. To date however, the extracellular signals and intracellular pathways regulating its expression and activity remain incompletely understood. We have previously showed that exposure to each of the three TGF-beta (transforming growth factor beta) isoforms upregulates XIAP protein content in endometrial carcinoma cells in vitro. In the present study, we have investigated the clinical relevance of TGF-beta isoforms in endometrial tumours and the mechanisms through which TGF-beta isoforms regulate XIAP content in uterine cancer cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1476-4598
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
216
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling.
pubmed:affiliation
Research group in Molecular Oncology and Endocrinology, Department of Chemistry-Biology, University of Quebec at Trois-Rivieres, Trois-Rivières, Quebec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't