Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-8-17
pubmed:abstractText
Immunoglobulins in secretions play a critical role in protection at mucosal surfaces. We examined the generation of viral-specific IgG and IgA in plasma and mucosal secretions of mice following systemic or mucosal immunization with lymphocytic choriomeningitis virus (LCMV), a widely used experimental model of viral infection. While there are early differences in humoral responses depending on the route of viral entry, we show that both routes generate comparably robust viral-specific IgG in plasma, vaginal, lung, and nasal secretions of immune mice. In contrast, LCMV elicited poor viral-specific IgA responses. Mice that were infected IN showed elevated viral-specific IgA in nasal and lung washes compared to IP-infected mice; however, LCMV-specific IgG overwhelmingly contributed to the humoral response in all mucosal secretions examined. Thus similarly to HIV-1, and several other mucosally-encountered microbial infections, these data suggest that LCMV infection fails to induce vigorous viral-specific IgA responses.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-10618553, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-10657630, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-11668342, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-11950804, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-12388726, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-12529646, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-14748066, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-14978084, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-15067066, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-15294987, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-15467838, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-15585085, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-15833098, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-16200081, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-16491139, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-16571790, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-16751848, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-17713535, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-18056354, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-18299574, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-18483500, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-18596964, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-18768876, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-19109126, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-19144318, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-19286559, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-19325114, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-19342648, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-19355789, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-19648924, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-19935657, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-20056191, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-20139992, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-20712477, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-6332167, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-8524802, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-9013967, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-9091805, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-9250174, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-9491999, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-9529153, http://linkedlifedata.com/resource/pubmed/commentcorrection/20712482-9765400
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1557-8976
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
377-84
pubmed:dateRevised
2011-8-3
pubmed:meshHeading
pubmed-meshheading:20712482-Administration, Intranasal, pubmed-meshheading:20712482-Animals, pubmed-meshheading:20712482-Antibodies, Viral, pubmed-meshheading:20712482-Antibody Specificity, pubmed-meshheading:20712482-Female, pubmed-meshheading:20712482-Immunity, Mucosal, pubmed-meshheading:20712482-Immunization, pubmed-meshheading:20712482-Immunoglobulin A, pubmed-meshheading:20712482-Immunoglobulin G, pubmed-meshheading:20712482-Injections, Intraperitoneal, pubmed-meshheading:20712482-Lung, pubmed-meshheading:20712482-Lymphocytic Choriomeningitis, pubmed-meshheading:20712482-Lymphocytic choriomeningitis virus, pubmed-meshheading:20712482-Mice, pubmed-meshheading:20712482-Mice, Inbred C57BL, pubmed-meshheading:20712482-Mucous Membrane, pubmed-meshheading:20712482-Nasal Mucosa, pubmed-meshheading:20712482-Vagina
pubmed:year
2010
pubmed:articleTitle
Both systemic and mucosal LCMV immunization generate robust viral-specific IgG in mucosal secretions, but elicit poor LCMV-specific IgA.
pubmed:affiliation
Department of Microbiology, The University of Tennessee, Knoxville, Tennessee 37996, USA. tonami@utk.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural