|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003451,
umls-concept:C0061179,
umls-concept:C0205460,
umls-concept:C0220781,
umls-concept:C0220825,
umls-concept:C0243044,
umls-concept:C0243072,
umls-concept:C0243077,
umls-concept:C0332464,
umls-concept:C0441655,
umls-concept:C1883254
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|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2010-8-16
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|
pubmed:abstractText |
Previous studies have suggested that geldanamycin (GA) inhibits the replication of several viruses in vitro. Here, we aimed to synthesize and evaluate the antiviral activity of 17-amino-17-demethoxygeldanamycin derivatives.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
2040-2066
|
|
pubmed:author |
pubmed-author:GaoLin-YanLY,
pubmed-author:GaoRong-MeiRM,
pubmed-author:JiangJian-DongJD,
pubmed-author:LiYan-PingYP,
pubmed-author:LiYu-HuanYH,
pubmed-author:LiZhuo-RongZR,
pubmed-author:MengShuaiS,
pubmed-author:PengZong-GenZG,
pubmed-author:ShanGuang-ZhiGZ,
pubmed-author:TaoPei-ZhenPZ,
pubmed-author:ZhangTianT,
pubmed-author:ZhuJian-HuaJH
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
259-68
|
|
pubmed:meshHeading |
pubmed-meshheading:20710066-Animals,
pubmed-meshheading:20710066-Antiviral Agents,
pubmed-meshheading:20710066-Benzoquinones,
pubmed-meshheading:20710066-Cell Line, Tumor,
pubmed-meshheading:20710066-Cercopithecus aethiops,
pubmed-meshheading:20710066-Ducks,
pubmed-meshheading:20710066-Enterovirus B, Human,
pubmed-meshheading:20710066-HIV-1,
pubmed-meshheading:20710066-HSP90 Heat-Shock Proteins,
pubmed-meshheading:20710066-Hepadnaviridae Infections,
pubmed-meshheading:20710066-Hepatitis B Virus, Duck,
pubmed-meshheading:20710066-Hepatitis Viruses,
pubmed-meshheading:20710066-Herpesviridae,
pubmed-meshheading:20710066-Humans,
pubmed-meshheading:20710066-Lactams, Macrocyclic,
pubmed-meshheading:20710066-Mice,
pubmed-meshheading:20710066-Microbial Sensitivity Tests,
pubmed-meshheading:20710066-Vero Cells,
pubmed-meshheading:20710066-Virus Replication
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|
pubmed:year |
2010
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|
pubmed:articleTitle |
Synthesis and biological evaluation of heat-shock protein 90 inhibitors: geldanamycin derivatives with broad antiviral activities.
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|
pubmed:affiliation |
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
