Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 17
pubmed:dateCreated
2010-8-16
pubmed:abstractText
Photophores (photogenic organs) of the lantern shark Etmopterus spinax are under hormonal control, with prolactin (PRL) and melatonin (MT) triggering the light emission. Differential sensitivity to these hormones in adult individuals suggests, however, that the luminescence of this shark is controlled by an additional mechanism. In this study, different techniques were used to investigate a potential modulator of E. spinax luminescence - nitric oxide (NO). NO synthase (NOS)-like immunoreactivity (IR) was found in the photocytes (photogenic cells) of the photophores. In addition, acetylated tubulin IR also supported the presence of nerves running through the photogenic tissue and innervating different structural elements of the photophores: photocytes, pigmented cells from the iris-like structure and lens cells. Pharmacological experiments confirmed a modulatory action of NO on the hormonally induced luminescence: NO donors sodium nitroprusside (SNP) and hydroxylamine decreased the time to reach the maximum amplitude (TL(max)) of MT-induced luminescence while these substances decreased the maximum amplitude of PRL-induced luminescence (and also the TL(max) in the case of SNP). The small impact of the NOS inhibitor l-NAME on hormonally induced luminescence suggests that NO is only produced on demand. The cGMP analogue 8BrcGMP mimicked the effects of NO donors suggesting that the effects of NO are mediated by cGMP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/1H-(1,2,4)oxadiazolo(4,3-a)quinoxali..., http://linkedlifedata.com/resource/pubmed/chemical/8-bromocyclic GMP, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase, http://linkedlifedata.com/resource/pubmed/chemical/Hydroxylamine, http://linkedlifedata.com/resource/pubmed/chemical/NG-Nitroarginine Methyl Ester, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Donors, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase, http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside, http://linkedlifedata.com/resource/pubmed/chemical/Oxadiazoles, http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1477-9145
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
213
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3005-11
pubmed:dateRevised
2011-1-6
pubmed:meshHeading
pubmed-meshheading:20709929-Animal Structures, pubmed-meshheading:20709929-Animals, pubmed-meshheading:20709929-Cyclic GMP, pubmed-meshheading:20709929-Embryo, Nonmammalian, pubmed-meshheading:20709929-Enzyme Inhibitors, pubmed-meshheading:20709929-Guanylate Cyclase, pubmed-meshheading:20709929-Hydroxylamine, pubmed-meshheading:20709929-Immunohistochemistry, pubmed-meshheading:20709929-Luminescence, pubmed-meshheading:20709929-NG-Nitroarginine Methyl Ester, pubmed-meshheading:20709929-Nitric Oxide, pubmed-meshheading:20709929-Nitric Oxide Donors, pubmed-meshheading:20709929-Nitric Oxide Synthase, pubmed-meshheading:20709929-Nitroprusside, pubmed-meshheading:20709929-Oxadiazoles, pubmed-meshheading:20709929-Quinoxalines, pubmed-meshheading:20709929-Sharks, pubmed-meshheading:20709929-Signal Transduction, pubmed-meshheading:20709929-Spectrum Analysis
pubmed:year
2010
pubmed:articleTitle
Nitric oxide in the control of luminescence from lantern shark (Etmopterus spinax) photophores.
pubmed:affiliation
Laboratory of Marine Biology, Earth and Life Institute, Université catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium. julien.m.claes@uclouvain.be
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't