|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
18
|
|
pubmed:dateCreated |
2010-8-30
|
|
pubmed:abstractText |
A novel series of pyrrolidine heterocycles was prepared and found to show potent inhibitory activity of CCR1 binding and CCL3 mediated chemotaxis of a CCR1-expressing cell line. A potent, optimized triazole lead from this series was found to have acceptable pharmacokinetics and microsomal stability in rat and is suitable for further optimization and development.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1464-3405
|
|
pubmed:author |
pubmed-author:AppellKenneth CKC,
pubmed-author:ChenWeiqingW,
pubmed-author:ChiriacCameliaC,
pubmed-author:DesaiHemaH,
pubmed-author:HicksCatherine MCM,
pubmed-author:JacobBijiB,
pubmed-author:JamesRayR,
pubmed-author:KimbleEarl FEF,
pubmed-author:LiuJinqiJ,
pubmed-author:LiuRuiyanR,
pubmed-author:MerrittJ RobertJR,
pubmed-author:O'BrienLindaL,
pubmed-author:OhlmeyerMichael JMJ,
pubmed-author:ParadkarVidyadhar MVM,
pubmed-author:PostelnekJenniferJ,
pubmed-author:QuadrosElizabethE,
pubmed-author:WebbMaria LML,
pubmed-author:WhiteNicoleN,
pubmed-author:WinesPamelaP,
pubmed-author:ZhangChongwuC
|
|
pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5477-9
|
|
pubmed:meshHeading |
pubmed-meshheading:20708929-Animals,
pubmed-meshheading:20708929-Cell Line,
pubmed-meshheading:20708929-Chemokine CCL3,
pubmed-meshheading:20708929-Chemotaxis,
pubmed-meshheading:20708929-Microsomes, Liver,
pubmed-meshheading:20708929-Pyrrolidines,
pubmed-meshheading:20708929-Rats,
pubmed-meshheading:20708929-Receptors, CCR1,
pubmed-meshheading:20708929-Triazoles
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Novel pyrrolidine heterocycles as CCR1 antagonists.
|
|
pubmed:affiliation |
Ligand Pharmaceuticals, Inc., 3000 Eastpark Blvd., Cranbury, NJ 08512, USA. jmerritt@kean.edu
|
|
pubmed:publicationType |
Journal Article
|
