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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-8-16
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pubmed:abstractText |
Self-rated health questions have been proven to be a highly reliable and valid measure of overall health as measured by other indicators in many population groups. It also has been shown to be a very good predictor of mortality, chronic or severe diseases, and the need for services, and is positively correlated with clinical assessments. Genetic factors have been estimated to account for 25-64% of the variance in the liability of self-rated health. The aim of the present study was to identify Single Nucleotide Polymorphisms (SNPs) underlying the heritability of self-rated health by conducting a genome-wide association analysis in a large sample of 6,706 Australian individuals aged 18-92. No genome wide significant SNPs associated with self-rated health could be identified, indicating that self-rated health may be influenced by a large number of SNPs with very small effect size. A very large sample will be needed to identify these SNPs.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-10848141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-11010695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-11130808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-12897600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-1430859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-1573207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-15935024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-16906466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-16941555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-17924335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-18300295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-18498207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-18680534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-19240061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-19571811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-19584075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-19618259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-19750555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-19896111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-8228003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-8878376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20707712-9403910
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1832-4274
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
398-403
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pubmed:dateRevised |
2011-8-3
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pubmed:meshHeading |
pubmed-meshheading:20707712-Adult,
pubmed-meshheading:20707712-Aged,
pubmed-meshheading:20707712-Australia,
pubmed-meshheading:20707712-Female,
pubmed-meshheading:20707712-Genome-Wide Association Study,
pubmed-meshheading:20707712-Health Status,
pubmed-meshheading:20707712-Humans,
pubmed-meshheading:20707712-Male,
pubmed-meshheading:20707712-Middle Aged,
pubmed-meshheading:20707712-Polymorphism, Single Nucleotide,
pubmed-meshheading:20707712-Self-Assessment
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pubmed:year |
2010
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pubmed:articleTitle |
A genome-wide association study of self-rated health.
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pubmed:affiliation |
Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. Miriam.Mosing@qimir.edu.au
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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