Source:http://linkedlifedata.com/resource/pubmed/id/20706984
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2010-9-2
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pubmed:abstractText |
Th17 cells and Th1 cells coordinate to play a critical role in the formation of inflammatory bowel diseases. To examine how Th17 and Th1 cells are regulated at inflammatory sites, we used Th1-dominant CD4(+)CD45RB(high) T cell-transferred RAG-2(-/-) and Th1/Th17-mixed IL-10(-/-) mice. Interestingly, not only did colitic RAG-2(-/-) mice that were parabiosed with WT mice show significant amelioration of colitis, but amelioration of disease was also observed in those parabiosed with colitic IL-10(-/-) mice. To assess the interference between Th1 and Th17 colitogenic T cells, we co-transferred colitogenic CD4(+) T cells from the lamina propria (LP) of CD4(+)CD45RB(high) T cell-transferred RAG-2(-/-) mice and IL-10(-/-) mice into RAG-2(-/-) mice. Surprisingly, the co-transferred RAG-2(-/-) mice showed a vast cellular infiltration of LP CD4(+) T cells similar to that seen in RAG-2(-/-) mice re-transferred with the cells from colitic RAG-2(-/-) mice alone, but the co-transferred RAG-2(-/-) mice did not have the wasting symptoms, which are also absent in RAG-2(-/-) mice transferred with cells from colitic IL-10(-/-) mice alone. Furthermore, the percentages of Th1 and Th17 cells originating from IL-10(-/-) mice and those of Th1 cells originating from colitic RAG-2(-/-) mice were all significantly decreased in the co-transferred mice as compared with the singly-transferred paired RAG-2(-/-) mice, suggesting that Th1 and Th17 cells are in competition, and that their orchestration results in a merged clinical phenotype of the two types of murine colitis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Rag2 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1521-4141
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pubmed:author |
pubmed-author:HayashiAtsushiA,
pubmed-author:HibiToshifumiT,
pubmed-author:HisamatsuTadakazuT,
pubmed-author:InoueNagamuN,
pubmed-author:KamadaNobuhikoN,
pubmed-author:KanaiTakanoriT,
pubmed-author:MatsuokaKatsuyoshiK,
pubmed-author:MikamiYoheiY,
pubmed-author:OgataHaruhikoH,
pubmed-author:OkamotoSusumuS,
pubmed-author:OkazawaAkiraA,
pubmed-author:OnoYuichiY,
pubmed-author:SujinoTomohisaT,
pubmed-author:TakaishiHiromasaH
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pubmed:issnType |
Electronic
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2409-22
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pubmed:meshHeading |
pubmed-meshheading:20706984-Adoptive Transfer,
pubmed-meshheading:20706984-Animals,
pubmed-meshheading:20706984-Antigens, CD4,
pubmed-meshheading:20706984-Antigens, CD45,
pubmed-meshheading:20706984-Cell Communication,
pubmed-meshheading:20706984-Colitis,
pubmed-meshheading:20706984-DNA-Binding Proteins,
pubmed-meshheading:20706984-Disease Models, Animal,
pubmed-meshheading:20706984-Humans,
pubmed-meshheading:20706984-Inflammatory Bowel Diseases,
pubmed-meshheading:20706984-Interleukin-10,
pubmed-meshheading:20706984-Interleukin-17,
pubmed-meshheading:20706984-Mice,
pubmed-meshheading:20706984-Mice, Inbred C57BL,
pubmed-meshheading:20706984-Mice, Knockout,
pubmed-meshheading:20706984-Mucous Membrane,
pubmed-meshheading:20706984-Parabiosis,
pubmed-meshheading:20706984-Th1 Cells
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pubmed:year |
2010
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pubmed:articleTitle |
Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.
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pubmed:affiliation |
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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