Linked Life Data

20706961

Source:http://linkedlifedata.com/resource/pubmed/id/20706961

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-8-13
pubmed:abstractText
A series of novel acyclic thymine nucleoside analogues were prepared by the Mitsunobu reaction from appropriately protected chiral triols. The enantiomeric triols were obtained from substituted gamma-lactone acids, prepared by asymmetric oxidation of 3-substituted-1,2-cyclopentanediones. The cytotoxic activity of new analogues was evaluated on MCF-7 human breast cancer and HeLa cells, and antiviral activities on human immunodeficiency virus type 1 and hepatitis C virus models. The synthesized compounds revealed specific anti-retroviral activity and no cytotoxic side effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1532-2335
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
707-20
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Synthesis of novel acyclic nucleoside analogues with anti-retroviral activity.
pubmed:affiliation
Department of Chemistry, Tallinn University of Technology, Tallinn, Estonia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't