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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-9-27
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pubmed:abstractText |
Emerging evidence suggests that phosphoinositide 3-kinase (PI3K) may modulate cardiac inotropy; however, the underlying mechanism remains elusive. We hypothesized that ?(2)-adrenergic receptor (AR)-coupled PI3K constrains increases in cardiac inotropy through cyclic adenosine monophosphate (cAMP)-dependent phosphodiesterase (PDE) activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1526-7598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
870-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20705779-Animals,
pubmed-meshheading:20705779-Cyclic AMP,
pubmed-meshheading:20705779-Cyclic Nucleotide Phosphodiesterases, Type 4,
pubmed-meshheading:20705779-Enzyme Activation,
pubmed-meshheading:20705779-GTP-Binding Protein alpha Subunits, Gi-Go,
pubmed-meshheading:20705779-HeLa Cells,
pubmed-meshheading:20705779-Humans,
pubmed-meshheading:20705779-Mice,
pubmed-meshheading:20705779-Mice, Inbred C57BL,
pubmed-meshheading:20705779-Myocardial Contraction,
pubmed-meshheading:20705779-Myocytes, Cardiac,
pubmed-meshheading:20705779-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:20705779-Receptors, Adrenergic, beta-2,
pubmed-meshheading:20705779-U937 Cells
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pubmed:year |
2010
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pubmed:articleTitle |
?2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation.
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pubmed:affiliation |
Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.
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