rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-12-17
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pubmed:abstractText |
prolonged P2Y-receptor signalling can cause vasoconstriction leading to hypertension, vascular smooth muscle hypertrophy, and hyperplasia. G protein-coupled receptor signalling is negatively regulated by G protein-coupled receptor kinases (GRKs) and arrestin proteins, preventing prolonged or inappropriate signalling. This study investigates whether GRKs and arrestins regulate uridine 5'-triphosphate (UTP)-stimulated contractile signalling in adult Wistar rat mesenteric arterial smooth muscle cells (MSMCs).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrbk1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Arrestins,
http://linkedlifedata.com/resource/pubmed/chemical/G-Protein-Coupled Receptor Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2Y,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2Y2,
http://linkedlifedata.com/resource/pubmed/chemical/Uridine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/beta-arrestin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
193-203
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pubmed:meshHeading |
pubmed-meshheading:20705669-Animals,
pubmed-meshheading:20705669-Arrestins,
pubmed-meshheading:20705669-Base Sequence,
pubmed-meshheading:20705669-Calcium Signaling,
pubmed-meshheading:20705669-G-Protein-Coupled Receptor Kinase 2,
pubmed-meshheading:20705669-Male,
pubmed-meshheading:20705669-Mesenteric Arteries,
pubmed-meshheading:20705669-Muscle, Smooth, Vascular,
pubmed-meshheading:20705669-Muscle Contraction,
pubmed-meshheading:20705669-RNA, Small Interfering,
pubmed-meshheading:20705669-Rats,
pubmed-meshheading:20705669-Rats, Wistar,
pubmed-meshheading:20705669-Receptors, Purinergic P2Y,
pubmed-meshheading:20705669-Receptors, Purinergic P2Y2,
pubmed-meshheading:20705669-Signal Transduction,
pubmed-meshheading:20705669-Uridine Triphosphate
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pubmed:year |
2011
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pubmed:articleTitle |
G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling.
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pubmed:affiliation |
Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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