Source:http://linkedlifedata.com/resource/pubmed/id/20704760
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2010-9-2
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| pubmed:abstractText |
The enzyme 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase (EC 4.1.2.15) catalyzes the first committed step in the shikimate pathway of tryptophan synthesis, an important precursor for the production of terpenoid indole alkaloids (TIAs). A full-length cDNA encoding nuclear coded chloroplast-specific DAHP synthase transcript was isolated from a Catharanthus roseus cDNA library. This had high sequence similarity with other members of plant DAHP synthase family. This transcript accumulated in suspension cultured C. roseus cells on ultraviolet (UV-B) irradiation. Pretreatment of C.roseus cells with variety of agents such as suramin, N-acetyl cysteine, and inhibitors of calcium fluxes and protein kinases and MAP kinase prevented this effect of UV-B irriadiation. These data further show that the essential components of the signaling pathway involved in accumulation DAHP synthase transcript in C. roseus cells include suramin-sensitive cell surface receptor, staurosporine-sensitive protein kinase and MAP kinase.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:issn |
1750-2187
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
5
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
13
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| pubmed:dateRevised |
2011-9-2
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| pubmed:year |
2010
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| pubmed:articleTitle |
UV-B induced transcript accumulation of DAHP synthase in suspension-cultured Catharanthus roseus cells.
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| pubmed:affiliation |
Department of Biochemistry, Indian Institute of Science, Bangalore-560012, India. cjb@biochem.iisc.ernet.in.
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| pubmed:publicationType |
Journal Article
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