Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-9-20
pubmed:abstractText
One of the visions of synthetic biology is to be able to program cells using a language that is similar to that used to program computers or robotics. For large genetic programs, keeping track of the DNA on the level of nucleotides becomes tedious and error prone, requiring a new generation of computer-aided design (CAD) software. To push the size of projects, it is important to abstract the designer from the process of part selection and optimization. The vision is to specify genetic programs in a higher-level language, which a genetic compiler could automatically convert into a DNA sequence. Steps towards this goal include: defining the semantics of the higher-level language, algorithms to select and assemble parts, and biophysical methods to link DNA sequence to function. These will be coupled to graphic design interfaces and simulation packages to aid in the prediction of program dynamics, optimize genes, and scan projects for errors.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-10068694, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-10659856, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-12029133, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-12181488, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-12451174, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-14512628, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-15738412, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-15790857, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-16140238, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-16330045, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-16545106, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-16756672, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-16845061, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-16978856, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-1702475, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-1703438, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-17081971, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-17313685, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-17408505, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-17719767, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-17804435, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-18173842, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-18242639, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-18271947, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-18522973, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-18687496, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-18712296, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-18757873, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-18796402, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-18971928, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-18998646, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-19073939, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-19081070, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-19208184, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-19264798, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-19363495, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-19429897, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-19445950, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-19478183, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-19563759, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-19633652, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-19693014, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-19720518, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-20090747, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-20133665, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-20167639, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-20211837, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-20335162, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-20504310, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-20569493, http://linkedlifedata.com/resource/pubmed/commentcorrection/20702081-2217199
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1879-0429
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
572-81
pubmed:dateRevised
2011-8-10
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Programming cells: towards an automated 'Genetic Compiler'.
pubmed:affiliation
Life Technologies, 5791 Van Allen Way, Carlsbad, CA 90028, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural