Source:http://linkedlifedata.com/resource/pubmed/id/20699522
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2010-8-11
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pubmed:abstractText |
A solitary fibrous tumor of the pleura (SFTP) is an uncommon tumor, in contrast to a relatively common mesothelioma in pleura. Its average size varies from 6 to 8 cm. We report herein a case of a giant SFTP in a 53-year-old man who presented with cough since five years along with chest pain on the left side and progressive dyspnea since two months. Radiological findings revealed a large pleural mass measuring 25 cm in its largest dimension, filling the pleural cavity with effusion. Biopsy showed a spindle cell tumor with areas of dense sclerosis. Subsequent excision unraveled a large multinodular, grey-white tumor, histologically, composed of spindle cells in a 'patternless' arrangement in dense collagenous stroma with areas of hyalinization. Focal areas showed hypercellularity with atypia and mitoses, but less than 4/10 High-Power Field, unassociated with necrosis. On immunohistochemistry, tumor cells showed diffuse positivity with vimentin, CD34 and BCL2 along with cytoplasmic positivity for MIC2 (CD99), whereas cytokeratin, EMA, calretinin and HBME-1 were negative. Diagnosis of an SFTP was substantiated over a close differential of a desmoplastic mesothelioma. In view of atypical features, a close follow-up of the case was recommended.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Protein, Vitamin...,
http://linkedlifedata.com/resource/pubmed/chemical/HBME-1 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Vimentin,
http://linkedlifedata.com/resource/pubmed/chemical/calretinin
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pubmed:status |
MEDLINE
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pubmed:issn |
0974-5130
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
544-7
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pubmed:meshHeading |
pubmed-meshheading:20699522-Antigens, CD34,
pubmed-meshheading:20699522-Biopsy,
pubmed-meshheading:20699522-Calcium-Binding Protein, Vitamin D-Dependent,
pubmed-meshheading:20699522-Chest Pain,
pubmed-meshheading:20699522-Cough,
pubmed-meshheading:20699522-Dyspnea,
pubmed-meshheading:20699522-Histocytochemistry,
pubmed-meshheading:20699522-Humans,
pubmed-meshheading:20699522-Immunohistochemistry,
pubmed-meshheading:20699522-Male,
pubmed-meshheading:20699522-Microscopy,
pubmed-meshheading:20699522-Middle Aged,
pubmed-meshheading:20699522-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:20699522-Radiography, Thoracic,
pubmed-meshheading:20699522-Solitary Fibrous Tumor, Pleural,
pubmed-meshheading:20699522-Tomography, X-Ray Computed,
pubmed-meshheading:20699522-Tumor Markers, Biological,
pubmed-meshheading:20699522-Vimentin
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pubmed:articleTitle |
A giant solitary fibrous tumor of the pleura: diagnostic implications in an unusual case with literature review.
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pubmed:affiliation |
Department of Pathology, Tata Memorial Hospital, Mumbai, India.
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pubmed:publicationType |
Journal Article,
Review,
Case Reports
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