Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-8-11
pubmed:abstractText
A solitary fibrous tumor of the pleura (SFTP) is an uncommon tumor, in contrast to a relatively common mesothelioma in pleura. Its average size varies from 6 to 8 cm. We report herein a case of a giant SFTP in a 53-year-old man who presented with cough since five years along with chest pain on the left side and progressive dyspnea since two months. Radiological findings revealed a large pleural mass measuring 25 cm in its largest dimension, filling the pleural cavity with effusion. Biopsy showed a spindle cell tumor with areas of dense sclerosis. Subsequent excision unraveled a large multinodular, grey-white tumor, histologically, composed of spindle cells in a 'patternless' arrangement in dense collagenous stroma with areas of hyalinization. Focal areas showed hypercellularity with atypia and mitoses, but less than 4/10 High-Power Field, unassociated with necrosis. On immunohistochemistry, tumor cells showed diffuse positivity with vimentin, CD34 and BCL2 along with cytoplasmic positivity for MIC2 (CD99), whereas cytokeratin, EMA, calretinin and HBME-1 were negative. Diagnosis of an SFTP was substantiated over a close differential of a desmoplastic mesothelioma. In view of atypical features, a close follow-up of the case was recommended.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0974-5130
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
544-7
pubmed:meshHeading
pubmed-meshheading:20699522-Antigens, CD34, pubmed-meshheading:20699522-Biopsy, pubmed-meshheading:20699522-Calcium-Binding Protein, Vitamin D-Dependent, pubmed-meshheading:20699522-Chest Pain, pubmed-meshheading:20699522-Cough, pubmed-meshheading:20699522-Dyspnea, pubmed-meshheading:20699522-Histocytochemistry, pubmed-meshheading:20699522-Humans, pubmed-meshheading:20699522-Immunohistochemistry, pubmed-meshheading:20699522-Male, pubmed-meshheading:20699522-Microscopy, pubmed-meshheading:20699522-Middle Aged, pubmed-meshheading:20699522-Proto-Oncogene Proteins c-bcl-2, pubmed-meshheading:20699522-Radiography, Thoracic, pubmed-meshheading:20699522-Solitary Fibrous Tumor, Pleural, pubmed-meshheading:20699522-Tomography, X-Ray Computed, pubmed-meshheading:20699522-Tumor Markers, Biological, pubmed-meshheading:20699522-Vimentin
pubmed:articleTitle
A giant solitary fibrous tumor of the pleura: diagnostic implications in an unusual case with literature review.
pubmed:affiliation
Department of Pathology, Tata Memorial Hospital, Mumbai, India.
pubmed:publicationType
Journal Article, Review, Case Reports