Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-31
pubmed:abstractText
Familial hypercholesterolemia (FH) is an autosomal codominant disease characterized by high concentrations of proatherogenic lipoproteins and premature atherosclerosis secondary to low-density lipoprotein (LDL) receptor deficiency. We examined a novel cell therapy strategy for the treatment of FH in the Watanabe heritable hyperlipidemic (WHHL) rabbit, an animal model for homozygous FH. We delivered human adipose tissue-derived multilineage progenitor cells (hADMPCs) via portal vein and followed by immunosuppressive regimen to avoid xenogenic rejection. Transplantation of hADMPCs resulted in significant reductions in total cholesterol, and the reductions were observed within 4 weeks and maintained for 12 weeks. (125)I-LDL turnover study showed that the rate of LDL clearance was significantly higher in the WHHL rabbits with transplanted hADMPCs than those without transplanted. After transplantation hADMPCs were localized in the portal triad, subsequently integrated into the hepatic parenchyma. The integrated cells expressed human albumin, human alpha-1-antitrypsin, human Factor IX, human LDL receptors, and human bile salt export pump, indicating that the transplanted hADMPCs resided, survived, and showed hepatocytic differentiation in vivo and lowered serum cholesterol in the WHHL rabbits. These results suggested that hADMPC transplantation could correct the metabolic defects and be a novel therapy for inherited liver diseases.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-12475952, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-14535658, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-15256765, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-1539224, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-15637308, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-15670778, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-16055896, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-1722351, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-17495232, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-17596885, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-18638251, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-19060422, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-19624256, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-19839740, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-19863253, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-1990718, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-206638, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-2144923, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-2236051, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-2243434, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-2643428, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-3513311, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-5534018, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-6390206, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-8175805, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-8349823, http://linkedlifedata.com/resource/pubmed/commentcorrection/20698754-8986740
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1937-3392
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-54
pubmed:dateRevised
2011-8-25
pubmed:meshHeading
pubmed-meshheading:20698754-Adipose Tissue, pubmed-meshheading:20698754-Adult, pubmed-meshheading:20698754-Animals, pubmed-meshheading:20698754-Biological Markers, pubmed-meshheading:20698754-Cell Differentiation, pubmed-meshheading:20698754-Cell Lineage, pubmed-meshheading:20698754-Cell Shape, pubmed-meshheading:20698754-Cell Survival, pubmed-meshheading:20698754-Cholesterol, pubmed-meshheading:20698754-Female, pubmed-meshheading:20698754-Hepatocytes, pubmed-meshheading:20698754-Humans, pubmed-meshheading:20698754-Hyperlipidemias, pubmed-meshheading:20698754-Immunohistochemistry, pubmed-meshheading:20698754-Immunosuppression, pubmed-meshheading:20698754-Male, pubmed-meshheading:20698754-Middle Aged, pubmed-meshheading:20698754-Rabbits, pubmed-meshheading:20698754-Stem Cell Transplantation, pubmed-meshheading:20698754-Stem Cells, pubmed-meshheading:20698754-Young Adult
pubmed:year
2011
pubmed:articleTitle
Transplantation of human adipose tissue-derived multilineage progenitor cells reduces serum cholesterol in hyperlipidemic Watanabe rabbits.
pubmed:affiliation
Department of Somatic Stem Cell Therapy and Health Policy, Foundation for Biomedical Research and Innovation, Kobe, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't