Linked Life Data

20698709

Source:http://linkedlifedata.com/resource/pubmed/id/20698709

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-4-6
pubmed:abstractText
The safe and effective use of pesticides requires knowledge of their mode of action in pests and adverse effects in nontarget organisms coupled with an understanding of their metabolic activation and detoxification. The author and his laboratory colleagues were privileged to observe, participate in, and sometimes influence these developments for the past six decades. This review considers contributions of the Berkeley and Madison laboratories to understanding insecticides acting at voltage-gated sodium and GABA-gated chloride channels and the nicotinic receptor and at serine hydrolases and other targets as well as the action of insecticide synergists and selected herbicides and fungicides. Some of the discoveries gave new probes, radioligands, photoaffinity labeling reagents, and understanding of reactive intermediates that changed the course of pesticide investigations and related areas of science. The importance of coupling mode of action with metabolism and design with serendipity is illustrated with a wide variety of chemotypes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1520-5118
pubmed:author
pubmed:issnType
Electronic
pubmed:day
13
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2762-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Curious about pesticide action.
pubmed:affiliation
Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720-3112, USA. ectl@berkeley.edu
pubmed:publicationType
Journal Article, Historical Article, Research Support, Non-U.S. Gov't