| pubmed-article:20696984 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20696984 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:20696984 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:20696984 | lifeskim:mentions | umls-concept:C0596790 | lld:lifeskim |
| pubmed-article:20696984 | lifeskim:mentions | umls-concept:C1521970 | lld:lifeskim |
| pubmed-article:20696984 | lifeskim:mentions | umls-concept:C0232108 | lld:lifeskim |
| pubmed-article:20696984 | lifeskim:mentions | umls-concept:C0020309 | lld:lifeskim |
| pubmed-article:20696984 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20696984 | pubmed:dateCreated | 2010-9-16 | lld:pubmed |
| pubmed-article:20696984 | pubmed:abstractText | The kidney is a key controller of the long-term level of arterial pressure, in part through pressure-natriuresis. Although direct coupling of changes in renal arterial pressure to renal interstitial hydrostatic pressure (RIHP) and consequent sodium excretion is well established, few studies have characterized the moment-to-moment aspects of this process. These studies characterized the short-term hemodynamic component of pressure-natriuresis in vivo before and after autonomic nervous system and renin-angiotensin system inhibition. Changes in RIHP were determined over a range of renal arterial pressures in Wistar rats receiving no treatment, a ganglionic blocker (hexamethonium; 20 mg/kg per hour IV), or an angiotensin II type 1 receptor blocker (losartan; 10 mg/kg per hour IV). After a series of changes in renal arterial pressure, a delay of only ?1 second was found for the onset of RIHP responses that was independent of the stimulus magnitude and neurohumoral manipulation; however, completion of the full RIHP response was within ?15 seconds for renal arterial pressure changes of ?30 mm Hg. The overall slope of the renal arterial pressure- RIHP relationship (0.09±0.01) was also not affected by autonomic nervous system and renin-angiotensin system inhibition despite decreasing renal arterial pressure (?40% and ?28%, respectively). Separate assessment of this relationship above and below the prevailing arterial pressure revealed that the pressor versus the depressor portion was blunted (P<0.001), a difference that was abolished after autonomic nervous system and renin-angiotensin system inhibition. The results suggest that spontaneous changes in arterial pressure are coupled to moment-to-moment changes in RIHP over a wide range of pressures, emphasizing a likely role for the dynamic component of the renal arterial pressure-RIHP relationship in the modulation of sodium excretion and, hence, arterial pressure. | lld:pubmed |
| pubmed-article:20696984 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20696984 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20696984 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20696984 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20696984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20696984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20696984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20696984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20696984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20696984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20696984 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20696984 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20696984 | pubmed:issn | 1524-4563 | lld:pubmed |
| pubmed-article:20696984 | pubmed:author | pubmed-author:AdamsMichael... | lld:pubmed |
| pubmed-article:20696984 | pubmed:author | pubmed-author:KomolovaMarin... | lld:pubmed |
| pubmed-article:20696984 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20696984 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:20696984 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20696984 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20696984 | pubmed:pagination | 650-7 | lld:pubmed |
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| pubmed-article:20696984 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20696984 | pubmed:articleTitle | Moment-to-moment characteristics of the relationship between arterial pressure and renal interstitial hydrostatic pressure. | lld:pubmed |
| pubmed-article:20696984 | pubmed:affiliation | Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario K7L3N6, Canada. | lld:pubmed |
| pubmed-article:20696984 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20696984 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
