Linked Life Data

20696984

Source:http://linkedlifedata.com/resource/pubmed/id/20696984

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-9-16
pubmed:abstractText
The kidney is a key controller of the long-term level of arterial pressure, in part through pressure-natriuresis. Although direct coupling of changes in renal arterial pressure to renal interstitial hydrostatic pressure (RIHP) and consequent sodium excretion is well established, few studies have characterized the moment-to-moment aspects of this process. These studies characterized the short-term hemodynamic component of pressure-natriuresis in vivo before and after autonomic nervous system and renin-angiotensin system inhibition. Changes in RIHP were determined over a range of renal arterial pressures in Wistar rats receiving no treatment, a ganglionic blocker (hexamethonium; 20 mg/kg per hour IV), or an angiotensin II type 1 receptor blocker (losartan; 10 mg/kg per hour IV). After a series of changes in renal arterial pressure, a delay of only ?1 second was found for the onset of RIHP responses that was independent of the stimulus magnitude and neurohumoral manipulation; however, completion of the full RIHP response was within ?15 seconds for renal arterial pressure changes of ?30 mm Hg. The overall slope of the renal arterial pressure- RIHP relationship (0.09±0.01) was also not affected by autonomic nervous system and renin-angiotensin system inhibition despite decreasing renal arterial pressure (?40% and ?28%, respectively). Separate assessment of this relationship above and below the prevailing arterial pressure revealed that the pressor versus the depressor portion was blunted (P<0.001), a difference that was abolished after autonomic nervous system and renin-angiotensin system inhibition. The results suggest that spontaneous changes in arterial pressure are coupled to moment-to-moment changes in RIHP over a wide range of pressures, emphasizing a likely role for the dynamic component of the renal arterial pressure-RIHP relationship in the modulation of sodium excretion and, hence, arterial pressure.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1524-4563
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
650-7
pubmed:meshHeading
pubmed-meshheading:20696984-Analysis of Variance, pubmed-meshheading:20696984-Angiotensin II, pubmed-meshheading:20696984-Angiotensin II Type 1 Receptor Blockers, pubmed-meshheading:20696984-Animals, pubmed-meshheading:20696984-Autonomic Nervous System, pubmed-meshheading:20696984-Blood Pressure, pubmed-meshheading:20696984-Ganglionic Blockers, pubmed-meshheading:20696984-Hemodynamics, pubmed-meshheading:20696984-Hexamethonium, pubmed-meshheading:20696984-Hydrostatic Pressure, pubmed-meshheading:20696984-Kidney, pubmed-meshheading:20696984-Losartan, pubmed-meshheading:20696984-Male, pubmed-meshheading:20696984-Natriuresis, pubmed-meshheading:20696984-Rats, pubmed-meshheading:20696984-Rats, Wistar, pubmed-meshheading:20696984-Renal Circulation, pubmed-meshheading:20696984-Renin-Angiotensin System, pubmed-meshheading:20696984-Time Factors, pubmed-meshheading:20696984-Vasoconstrictor Agents
pubmed:year
2010
pubmed:articleTitle
Moment-to-moment characteristics of the relationship between arterial pressure and renal interstitial hydrostatic pressure.
pubmed:affiliation
Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario K7L3N6, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't