Source:http://linkedlifedata.com/resource/pubmed/id/20696254
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2010-10-22
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pubmed:abstractText |
Electrocorticogram (ECoG) is a well-balanced methodology for stably mapping brain surface local field potentials (LFPs) over a wide cortical region with high signal fidelity and minimal invasiveness to the brain tissue. To directly compare surface ECoG signals with intracortical neuronal activity immediately underneath, we fabricated a flexible multichannel electrode array with mesh-form structure using micro-electro-mechanical systems. A Parylene-C-based "electrode-mesh" for rats contained a 6×6 gold electrode array with 1-mm interval. Specifically, the probe had 800×800 ?m(2) fenestrae in interelectrode spaces, through which simultaneous penetration of microelectrode was capable. This electrode-mesh was placed acutely or chronically on the dural/pial surface of the visual cortex of Long-Evans rats for up to 2 weeks. We obtained reliable trial-wise profiles of visually evoked ECoG signals through individual eye stimulation. Visually evoked ECoG signals from the electrode-mesh exhibited as well or larger signal amplitudes as intracortical LFPs and less across-trial variability than conventional silver-ball ECoG. Ocular selectivity of ECoG responses was correlated with that of intracortical spike/LFP activities. Moreover, single-trial ECoG signals carried sufficient information for predicting the stimulated eye with a correct performance approaching 90%, and the decoding was significantly generalized across sessions over 6 hours. Electrode impedance or signal quality did not obviously deteriorate for 2 weeks following implantation. These findings open up a methodology to directly explore ECoG signals with reference to intracortical neuronal sources and would provide a key to developing minimally invasive next-generation brain-machine interfaces.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1095-9572
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pubmed:author | |
pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
203-12
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pubmed:meshHeading |
pubmed-meshheading:20696254-Animals,
pubmed-meshheading:20696254-Dominance, Ocular,
pubmed-meshheading:20696254-Electrocardiography,
pubmed-meshheading:20696254-Electrodes,
pubmed-meshheading:20696254-Monitoring, Physiologic,
pubmed-meshheading:20696254-Neurons,
pubmed-meshheading:20696254-Photic Stimulation,
pubmed-meshheading:20696254-Rats,
pubmed-meshheading:20696254-Scalp,
pubmed-meshheading:20696254-Signal Transduction,
pubmed-meshheading:20696254-Visual Cortex,
pubmed-meshheading:20696254-Visual Fields
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pubmed:year |
2011
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pubmed:articleTitle |
Simultaneous recording of ECoG and intracortical neuronal activity using a flexible multichannel electrode-mesh in visual cortex.
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pubmed:affiliation |
Department of Physiology, Niigata University School of Medicine, Niigata, Japan. toda@med.niigata-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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