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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-8-9
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pubmed:abstractText |
The risk for mental illnesses such as depression is increasingly conceptualized as the product of gene-environment interactions and their impact on brain structure and function. The role of serotonin 3A receptor gene (HTR3A -42C>T polymorphism) and its interaction with early life stress (ELS) was investigated in view of the receptor's localization to brain regions central to emotion processing.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1520-6394
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pubmed:author |
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pubmed:copyrightInfo |
2010 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
752-9
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pubmed:meshHeading |
pubmed-meshheading:20694966-Adult,
pubmed-meshheading:20694966-Brain,
pubmed-meshheading:20694966-Depressive Disorder,
pubmed-meshheading:20694966-Emotions,
pubmed-meshheading:20694966-Female,
pubmed-meshheading:20694966-Frontal Lobe,
pubmed-meshheading:20694966-Gene Frequency,
pubmed-meshheading:20694966-Genetic Predisposition to Disease,
pubmed-meshheading:20694966-Genotype,
pubmed-meshheading:20694966-Humans,
pubmed-meshheading:20694966-Life Change Events,
pubmed-meshheading:20694966-Limbic System,
pubmed-meshheading:20694966-Magnetic Resonance Imaging,
pubmed-meshheading:20694966-Male,
pubmed-meshheading:20694966-Middle Aged,
pubmed-meshheading:20694966-Nerve Net,
pubmed-meshheading:20694966-Organ Size,
pubmed-meshheading:20694966-Receptors, Serotonin, 5-HT3,
pubmed-meshheading:20694966-Regression Analysis,
pubmed-meshheading:20694966-Risk Factors,
pubmed-meshheading:20694966-Social Environment
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pubmed:year |
2010
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pubmed:articleTitle |
Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood.
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pubmed:affiliation |
The Brain Dynamics Center, Westmead Millennium Institute & Discipline of Psychiatry, University of Sydney at Westmead Hospital, New South Wales, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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