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rdf:type |
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lifeskim:mentions |
umls-concept:C0001483,
umls-concept:C0020964,
umls-concept:C0020971,
umls-concept:C0026724,
umls-concept:C0086022,
umls-concept:C0205263,
umls-concept:C0442335,
umls-concept:C0521346,
umls-concept:C1332714,
umls-concept:C1517499,
umls-concept:C1705099
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|
pubmed:issue |
8
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|
pubmed:dateCreated |
2010-8-9
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|
pubmed:abstractText |
Virus-vectored vaccine is a powerful activator of CD8 T cell-mediated immunity and is especially amenable to respiratory mucosal immunization, offering hopes for use in humans with diminished helper CD4 T cell function. However, whether virus-mediated mucosal immunization can produce immune protective CD8 T cells without the CD4 T cell help remains to be investigated.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1521-2254
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pubmed:author |
|
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pubmed:copyrightInfo |
Copyright 2010 John Wiley & Sons, Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
12
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
693-704
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pubmed:meshHeading |
pubmed-meshheading:20694950-Acyltransferases,
pubmed-meshheading:20694950-Adenoviridae,
pubmed-meshheading:20694950-Administration, Intranasal,
pubmed-meshheading:20694950-Animals,
pubmed-meshheading:20694950-Antigens, Bacterial,
pubmed-meshheading:20694950-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20694950-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:20694950-Female,
pubmed-meshheading:20694950-Genetic Vectors,
pubmed-meshheading:20694950-Immunization,
pubmed-meshheading:20694950-Lymphocyte Depletion,
pubmed-meshheading:20694950-Mice,
pubmed-meshheading:20694950-Mice, Inbred BALB C,
pubmed-meshheading:20694950-Respiratory Mucosa,
pubmed-meshheading:20694950-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:20694950-Tuberculosis Vaccines
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pubmed:year |
2010
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pubmed:articleTitle |
Respiratory mucosal immunization with adenovirus gene transfer vector induces helper CD4 T cell-independent protective immunity.
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pubmed:affiliation |
Department of Pathology & Molecular Medicine, Centre for Gene Therapeutics & M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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