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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-7-1
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pubmed:abstractText |
(99m)Tc-3PRGD(2) is a (99m)Tc-labeled dimeric cyclic RGD peptide with increased receptor binding affinity and improved kinetics for in vivo imaging of integrin ?(v)?(3) expression in nude mouse model. To accelerate its clinical translation, we reported here the evaluation of the kit-formulated (99m)Tc-3PRGD(2) in healthy cynomolgus primates for its blood clearance kinetics, biodistribution, and radiation dosimetry.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1860-2002
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
730-6
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pubmed:meshHeading |
pubmed-meshheading:20694579-Absorption,
pubmed-meshheading:20694579-Animals,
pubmed-meshheading:20694579-Chromatography, High Pressure Liquid,
pubmed-meshheading:20694579-Dose-Response Relationship, Radiation,
pubmed-meshheading:20694579-Humans,
pubmed-meshheading:20694579-Integrin alphaVbeta3,
pubmed-meshheading:20694579-Kinetics,
pubmed-meshheading:20694579-Macaca fascicularis,
pubmed-meshheading:20694579-Mice,
pubmed-meshheading:20694579-Molecular Imaging,
pubmed-meshheading:20694579-Organotechnetium Compounds,
pubmed-meshheading:20694579-Peptides, Cyclic,
pubmed-meshheading:20694579-Protein Multimerization,
pubmed-meshheading:20694579-Radiometry,
pubmed-meshheading:20694579-Reagent Kits, Diagnostic,
pubmed-meshheading:20694579-Tissue Distribution,
pubmed-meshheading:20694579-Whole Body Imaging
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pubmed:year |
2011
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pubmed:articleTitle |
Blood clearance kinetics, biodistribution, and radiation dosimetry of a kit-formulated integrin ?v?3-selective radiotracer 99mTc-3PRGD 2 in non-human primates.
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pubmed:affiliation |
Medical Isotopes Research Center, Peking University, Beijing, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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