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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-9-16
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pubmed:abstractText |
There is increasing evidence for the crucial role of metals in the pathology of Alzheimer's disease. Both the aggregation and neurotoxicity of amyloid-? are dependent on the presence of copper. This study investigated the ability of the copper-complexing drug tetrathiomolybdate to reduce amyloid-? pathology and spatial memory impairment in both a prevention and a treatment paradigm in the Tg2576 mouse model of Alzheimer's disease. Tetrathiomolybdate treatment lowered brain copper and reduced amyloid-? levels in the prevention paradigm, but not in the treatment paradigm. Our data suggests that controlled lowering of systemic copper may achieve anti-amyloid effects if initiated early in the disease process.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-11424945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-11430801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-11755007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-12215434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-12633149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-14617772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-14617773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-14676042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-14717612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-14985339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-15231727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-16606763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-16648635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-17162252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-18086681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-18248325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-18614028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-18672400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-18953111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-19010295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-19122148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-19183260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-19402774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-20130173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-4214636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20693639-6016596
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1875-8908
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
903-14
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20693639-Alzheimer Disease,
pubmed-meshheading:20693639-Amyloid beta-Peptides,
pubmed-meshheading:20693639-Analysis of Variance,
pubmed-meshheading:20693639-Animals,
pubmed-meshheading:20693639-Blotting, Western,
pubmed-meshheading:20693639-Cerebral Cortex,
pubmed-meshheading:20693639-Ceruloplasmin,
pubmed-meshheading:20693639-Chelating Agents,
pubmed-meshheading:20693639-Copper,
pubmed-meshheading:20693639-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20693639-Hippocampus,
pubmed-meshheading:20693639-Immunohistochemistry,
pubmed-meshheading:20693639-Maze Learning,
pubmed-meshheading:20693639-Memory Disorders,
pubmed-meshheading:20693639-Mice,
pubmed-meshheading:20693639-Mice, Transgenic,
pubmed-meshheading:20693639-Molybdenum,
pubmed-meshheading:20693639-Random Allocation
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pubmed:year |
2010
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pubmed:articleTitle |
A copper-lowering strategy attenuates amyloid pathology in a transgenic mouse model of Alzheimer's disease.
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pubmed:affiliation |
Portland Veterans Affairs Medical Center, P3 R&D, Portland, OR, USA. quinnj@ohsu.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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