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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-2-23
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pubmed:abstractText |
The level of minimal residual disease (MRD) in acute myeloid leukemia (AML) at early time points (TPs) may be an important prognostic factor. Although internal tandem duplication of FLT3 (FLT3-ITD) as an MRD marker has been questioned for its instability based on semi-quantitative methods, we hypothesized that FLT3-ITD dynamics measured by sensitive quantitative real-time PCR at early TPs before appearance of instability may provide prognostic information.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1569-8041
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
696-704
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pubmed:meshHeading |
pubmed-meshheading:20693296-Adolescent,
pubmed-meshheading:20693296-Adult,
pubmed-meshheading:20693296-Aged,
pubmed-meshheading:20693296-Aged, 80 and over,
pubmed-meshheading:20693296-Amino Acid Sequence,
pubmed-meshheading:20693296-Disease-Free Survival,
pubmed-meshheading:20693296-Female,
pubmed-meshheading:20693296-Genetic Association Studies,
pubmed-meshheading:20693296-Genetic Markers,
pubmed-meshheading:20693296-Humans,
pubmed-meshheading:20693296-Kaplan-Meier Estimate,
pubmed-meshheading:20693296-Leukemia, Myeloid, Acute,
pubmed-meshheading:20693296-Male,
pubmed-meshheading:20693296-Middle Aged,
pubmed-meshheading:20693296-Molecular Sequence Data,
pubmed-meshheading:20693296-Multivariate Analysis,
pubmed-meshheading:20693296-Mutagenesis, Insertional,
pubmed-meshheading:20693296-Neoplasm, Residual,
pubmed-meshheading:20693296-Nuclear Proteins,
pubmed-meshheading:20693296-Prognosis,
pubmed-meshheading:20693296-Sequence Analysis, DNA,
pubmed-meshheading:20693296-Young Adult,
pubmed-meshheading:20693296-fms-Like Tyrosine Kinase 3
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pubmed:year |
2011
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pubmed:articleTitle |
Sensitive measurement of quantity dynamics of FLT3 internal tandem duplication at early time points provides prognostic information.
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pubmed:affiliation |
Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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