Mesangial cell functions are critically regulated by platelet-derived growth factor receptor (PDGFR)-? signals. In contrast to the well-established role of PDGFR-? in the development of kidney glomerulus, its role in adult kidney glomerulus remains controversial.
Second Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Sciences for Research, University ofToyama, and Fujikoshi Hospital, 2630, Sugitani, Toyama 930-0194, Japan. taizo@med.u-toyama.ac.jp