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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1991-8-15
|
| pubmed:abstractText |
Among 145 patients with the complex of myxomas, spotty pigmentation, endocrine overactivity, and psammomatous melanotic schwannomas, 31 (21%) had mammary lesions. The ages of these 26 females and five males ranged from 6 to 64 years (mean, 30 years). Five patients had breast symptoms. In 21 (81%) of the females, benign mesenchymal lesion(s) were detected pathologically. These were characterized by accumulations of large amounts of ground substance in the lobules that alterated the stroma to a very loose and myxoid tissue. The change involved single lobules (lobular myxoid change), small groups of lobules (nodular myxoid change), and large aggregates of lobules (myxoid fibroadenoma); the interlobular stroma was affected to a lesser degree. The lesions were multicentric and bilateral in eight patients (38%). Because the myxoid breast lesions were familial, were frequent findings in the complex, and were similar histologically to the cardiac and cutaneous myxomas in the complex, they undoubtedly are a component and a pathologic marker of the complex. They were the presenting feature of the complex in six patients (19%). Therefore, discovery of the myxoid breast lesions on pathologic examination should raise suspicion of the complex, and affected patients (and their primary relatives) should be evaluated accordingly.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0147-5185
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
713-21
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2069209-Adenofibroma,
pubmed-meshheading:2069209-Adolescent,
pubmed-meshheading:2069209-Adult,
pubmed-meshheading:2069209-Breast Neoplasms,
pubmed-meshheading:2069209-Child,
pubmed-meshheading:2069209-Child, Preschool,
pubmed-meshheading:2069209-Cushing Syndrome,
pubmed-meshheading:2069209-Family Health,
pubmed-meshheading:2069209-Female,
pubmed-meshheading:2069209-Heart Neoplasms,
pubmed-meshheading:2069209-Humans,
pubmed-meshheading:2069209-Lentigo,
pubmed-meshheading:2069209-Male,
pubmed-meshheading:2069209-Mastectomy,
pubmed-meshheading:2069209-Melanoma,
pubmed-meshheading:2069209-Middle Aged,
pubmed-meshheading:2069209-Myxoma,
pubmed-meshheading:2069209-Neoplasms, Multiple Primary,
pubmed-meshheading:2069209-Neuroma,
pubmed-meshheading:2069209-Skin Neoplasms,
pubmed-meshheading:2069209-Syndrome
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Myxoid fibroadenoma and allied conditions (myxomatosis) of the breast. A heritable disorder with special associations including cardiac and cutaneous myxomas.
|
| pubmed:affiliation |
Section of Surgical Pathology, Mayo Clinic, Rochester, MN 55905.
|
| pubmed:publicationType |
Journal Article
|