Linked Life Data

20691581

Source:http://linkedlifedata.com/resource/pubmed/id/20691581

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-9-27
pubmed:abstractText
The discovery of the light-gated cation channel Channelrhodopsin-2 (ChR2) and the use of the rediscovered light-driven Cl-pump halorhodopsin (HR) as optogenetic tools--genetically encoded switches that enable neurons to be turned on or off with bursts of light--refines the functional study of neurons in larger networks. Cell-specific expression allows a fast optical scanning approach to determine neuronal crosstalk following plasticity at the single synapse level or long-range projections in locomotion and somatosensory networks. Both rhodopsins proved to work functionally and could evoke behavioral responses in lower model organisms, reinstall rudimentary visual perception in blind mice and were set in a biomedical context with the investigation of neurodegenerative diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1873-6882
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
610-6
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Microbial rhodopsins in the spotlight.
pubmed:affiliation
Max-Planck-Institut für Biophysik, Max-von-Laue Strasse 3, 60438 Frankfurt, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't