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pubmed:abstractText |
Bacterial genomes possess varying GC content (total guanines (Gs) and cytosines (Cs) per total of the four bases within the genome) but within a given genome, GC content can vary locally along the chromosome, with some regions significantly more or less GC rich than on average. We have examined how the GC content varies within microbial genomes to assess whether this property can be associated with certain biological functions related to the organism's environment and phylogeny. We utilize a new quantity GCVAR, the intra-genomic GC content variability with respect to the average GC content of the total genome. A low GCVAR indicates intra-genomic GC homogeneity and high GCVAR heterogeneity.
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pubmed:affiliation |
Norwegian School of Veterinary Science, Department of Food Safety and Infection Biology, Ullevålsveien 72, P,O, Box 8146 Dep, NO-0033 Oslo, Norway. jon.bohlin@veths.no
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