|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0021469,
umls-concept:C0026336,
umls-concept:C0032659,
umls-concept:C0070829,
umls-concept:C0201734,
umls-concept:C0439810,
umls-concept:C0441471,
umls-concept:C0441655,
umls-concept:C0965618,
umls-concept:C1527148,
umls-concept:C1870362
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2010-8-9
|
|
pubmed:abstractText |
Roflumilast is an oral, selective phosphodiesterase (PDE)-4 inhibitor in development for the treatment of chronic obstructive pulmonary disease (COPD). Both roflumilast and its metabolite roflumilast N-oxide have anti-inflammatory properties that contribute to overall pharmacological activity.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0312-5963
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
49
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
589-606
|
|
pubmed:meshHeading |
pubmed-meshheading:20690782-Adult,
pubmed-meshheading:20690782-Aged,
pubmed-meshheading:20690782-Aminopyridines,
pubmed-meshheading:20690782-Area Under Curve,
pubmed-meshheading:20690782-Benzamides,
pubmed-meshheading:20690782-Cyclopropanes,
pubmed-meshheading:20690782-Female,
pubmed-meshheading:20690782-Humans,
pubmed-meshheading:20690782-Male,
pubmed-meshheading:20690782-Middle Aged,
pubmed-meshheading:20690782-Models, Biological,
pubmed-meshheading:20690782-Phosphodiesterase 4 Inhibitors,
pubmed-meshheading:20690782-Phosphodiesterase Inhibitors,
pubmed-meshheading:20690782-Pulmonary Disease, Chronic Obstructive
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Population pharmacokinetic modelling of roflumilast and roflumilast N-oxide by total phosphodiesterase-4 inhibitory activity and development of a population pharmacodynamic-adverse event model.
|
|
pubmed:affiliation |
Department of Pharmacometrics and Pharmacokinetics, Nycomed GmbH, Byk-Gulden-Strasse 2, Konstanz, Germany. gezim.lahu@nycomed.com
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
